Date published: 2026-1-20

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4-Hydroxypyridine (CAS 626-64-2)

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Alternate Names:
4-Pyridinol; 4-Pyridone
CAS Number:
626-64-2
Molecular Weight:
95.10
Molecular Formula:
C5H5NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Hydroxypyridine is widely used in organic chemistry research, particularly in the synthesis of heterocyclic compounds. This compound serves as a intermediate in the preparation of various biologically relevant molecules, including vitamins and coenzymes. Studies involving 4-Hydroxypyridine often focus on its properties as a nucleophilic agent and its potential in substitution reactions that are central to building complex molecular structures. Additionally, 4-Hydroxypyridine is utilized in catalysis research, where its ability to act as a ligand can influence the outcomes of catalytic processes, enhancing both the rate and selectivity of reactions.


4-Hydroxypyridine (CAS 626-64-2) References

  1. Studies on the activity of three palladium(II) compounds of the form: trans-PdL2Cl2 where L=2-hydroxypyridine, 3-hydroxypyridine, and 4-hydroxypyridine.  |  Huq, F., et al. 2007. J Inorg Biochem. 101: 30-5. PMID: 16997377
  2. 4-Pyridone-terephthalic acid-water (2/1/2) and bis(3-hydroxypyridinium) terephthalate.  |  Staun, SL. and Oliver, AG. 2012. Acta Crystallogr C. 68: o84-7. PMID: 22307259
  3. The role of substrate strain in the mechanism of the carbon-carbon lyases.  |  Phillips, RS., et al. 2014. Bioorg Chem. 57: 198-205. PMID: 25035301
  4. Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries.  |  Paul Friedman, K., et al. 2016. Toxicol Sci. 151: 160-80. PMID: 26884060
  5. Biochemical and Genetic Analysis of 4-Hydroxypyridine Catabolism in Arthrobacter sp. Strain IN13.  |  Vaitekūnas, J., et al. 2020. Microorganisms. 8: PMID: 32545463
  6. Mirror-like Bright Al-Mn Coatings Electrodeposition from 1-Ethyl-3 Methylimidazolium Chloride-AlCl3-MnCl2 Ionic Liquids with Pyridine Derivatives.  |  Peng, D., et al. 2021. Materials (Basel). 14: PMID: 34683818
  7. Neodymium β-diketonate showing slow magnetic relaxation and acting as a ratiometric thermometer based on near-infrared emission.  |  Kumar, K., et al. 2019. RSC Adv. 9: 23444-23449. PMID: 35530587
  8. Microbial metabolism of the pyridine ring. The hydroxylation of 4-hydroxypyridine to pyridine-3,4-diol (3,4-dihydroxypyridine) by 4-hydroxypyridine-3-hydroxylase.  |  Watson, GK., et al. 1974. Biochem J. 140: 265-76. PMID: 4156169
  9. Response to polar-inductive and mesomeric effects of contiguous substituents in parent oxygen acids XOH and nitroactivated parent carbon acids XCH2NO2. The phenylogy principle  |  Bradamante, S., & Pagani, G. A. 1979. The Journal of Organic Chemistry. 44(25): 4737-4740.
  10. Vanadium-51 NMR investigation of the interactions of vanadate with hydroxypyridines and pyridinecarboxylates in aqueous solution  |  Galeffi, B., & Tracey, A. S. 1989. Inorganic Chemistry. 28(9): 1726-1734.
  11. Intermediate pyrolysis of Acacia cincinnata and Acacia holosericea species for bio-oil and biochar production  |  A Ahmed, MSA Bakar, AK Azad, RS Sukri. 2018. Energy Conversion and Management. 176: 393-408.
  12. Intensification of High Boiling Point Organic Solvents on SO2 Absorption in Deep Eutectic Solvents Formed by Hydroxypyridine and 1-Butyl-3-methylimidazolium Chloride  |  Jiang, B., Zhang, C., Tantai, X., Yang, N., Zhang, L., Sun, Y., & Xiao, X. 2022. Journal of Chemical & Engineering Data. 67(11): 3435-3442.
  13. Tuning functional ionic deep eutectic solvents as green sorbents and catalysts for highly efficient capture and transformation of CO2 to quinazoline-2, 4 (1H, 3H)-dione and its derivatives  |  Cui, G., Xu, Y., Hu, D., Zhou, Y., Ge, C., Liu, H.,.. & Lu, H. 2023. Chemical Engineering Journal. 469: 143991.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Hydroxypyridine, 25 g

sc-238870
25 g
$42.00

4-Hydroxypyridine, 100 g

sc-238870A
100 g
$131.00