Date published: 2025-11-17

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4-Chloro-3-methylphenol (CAS 59-50-7)

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Alternate Names:
4-Chloro-m-cresol
CAS Number:
59-50-7
Molecular Weight:
142.58
Molecular Formula:
C7H7ClO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Chloro-3-methylphenol presents as a white crystalline solid characterized by solubility in water and many organic solvents. This compound, classified as a hydroxytoluene and a monochlorobenzene derivative, has various useful applications. It is a preservative, antiseptic, and disinfectant. It is used in the production of cosmetics, food items, and the preservation of biological samples. Additionally, 4-Chloro-3-methylphenol holds significance as a ryanodine receptor agonist.


4-Chloro-3-methylphenol (CAS 59-50-7) References

  1. Solid-phase microextraction of the antifouling Irgarol 1051 and the fungicides dichlofluanid and 4-chloro-3-methylphenol in water samples.  |  Peñalver, A., et al. 1999. J Chromatogr A. 839: 253-60. PMID: 10327630
  2. Oxidation of 4-chloro-3-methylphenol in pressurized hot water/supercritical water with potassium persulfate as oxidant.  |  Kronholm, J., et al. 2001. Environ Sci Technol. 35: 3247-51. PMID: 11506014
  3. Supramolecular structures of 2-chloro-5-methylphenol and 4-chloro-3-methylphenol (chlorocresol).  |  Cox, PJ. 2003. Acta Crystallogr C. 59: o533-6. PMID: 12944669
  4. In vitro dermal penetration of 4-chloro-3-methylphenol from commercial metal working fluid and aqueous vehicles.  |  Frasch, HF., et al. 2010. J Toxicol Environ Health A. 73: 1394-405. PMID: 20818538
  5. Assessment of cross-reactivity in a tailor-made molecularly imprinted polymer for phenolic compounds using four adsorption isotherm models.  |  Abu-Alsoud, GF., et al. 2020. J Chromatogr A. 1629: 461463. PMID: 32841770
  6. Evaluating couch polyurethane foam for a potential passive sampler of semivolatile organic compounds.  |  Kim, K., et al. 2021. Chemosphere. 271: 129349. PMID: 33429263
  7. Summary of reference chemicals evaluated by the fish short-term reproduction assay, OECD TG229, using Japanese Medaka, Oryzias latipes.  |  Onishi, Y., et al. 2021. J Appl Toxicol. 41: 1200-1221. PMID: 33486801
  8. Skin irritation and inhalation toxicity of biocides evaluated with reconstructed human epidermis and airway models.  |  Hwang, JH., et al. 2021. Food Chem Toxicol. 150: 112064. PMID: 33596452
  9. Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells.  |  Lee, J., et al. 2022. Arch Toxicol. 96: 1039-1053. PMID: 35182163
  10. Improved Method for Preparation of 3-(1H-Indol-3-yl)benzofuran-2(3H)-ones.  |  Grishin, IY., et al. 2022. Molecules. 27: PMID: 35335265
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  12. Incorporation of carbon black into a sonogel matrix: improving antifouling properties of a conducting polymer ceramic nanocomposite.  |  Sierra-Padilla, A., et al. 2023. Mikrochim Acta. 190: 168. PMID: 37012526
  13. Innovative Cadaver Preservation Techniques: a Systematic Review.  |  Kaliappan, A., et al. 2023. Maedica (Bucur). 18: 127-135. PMID: 37266469

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Chloro-3-methylphenol, 5 g

sc-238806
5 g
$20.00

4-Chloro-3-methylphenol, 100 g

sc-238806A
100 g
$26.00