Molecular structure of Sodium mercaptopyruvate, CAS Number: 10255-67-1
Sodium mercaptopyruvate (CAS 10255-67-1)
See product citations (6)
Alternate Names:
Sodium mercaptopyruvate also known as 3-Mercapto-2-oxopropionic acid sodium salt; Mercaptopyruvic acid sodium salt; Mercaptopyruvic acid
Application:
Sodium mercaptopyruvate is a cysteine and methionine metabolism metabolite and an important mercaptopyruvate pathway intermediate
CAS Number:
10255-67-1
Purity:
≥90%
Molecular Weight:
142.11
Molecular Formula:
C3H3O3S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sodium mercaptopyruvate is an important mercaptopyruvate pathway intermediate during which cysteine of aspartate transaminase catalyses the transamination from cysteine to mercaptopyruvate and then mercaptopyruvate sulfurtransferase catalyzes the transsulfuration from mercaptupyruvate to pyruvate. This process works to maintain the cellular redox status. Sodium mercaptopyruvate exists as an equilibrium of its enol and keto form, where the dominant form being the keto (2,5-Dihydroxy-[1,4]dithiane-2,5-dicarboxylate).
Sodium mercaptopyruvate (CAS 10255-67-1) References
- Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities. | Nakamura, T., et al. 2000. Eur J Biochem. 267: 5621-30. PMID: 10951223
- Age-related changes in toxicity and biotransformation of potassium cyanide in male C57BL/6N mice. | McMahon, TF. and Birnbaum, LS. 1990. Toxicol Appl Pharmacol. 105: 305-14. PMID: 2171158
- Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice. | Eklind, KI., et al. 1990. Carcinogenesis. 11: 2033-6. PMID: 2225337
- A novel method for the analysis of 3-mercaptopyruvate using high-performance liquid chromatography with fluorescence detection. | Ogasawara, Y., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 931: 56-60. PMID: 23764732
- Dose and time-dependent effects of cyanide on thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cystathionine λ-lyase activities. | Singh, P., et al. 2013. J Biochem Mol Toxicol. 27: 499-507. PMID: 23929717
- Assay methods for H2S biogenesis and catabolism enzymes. | Banerjee, R., et al. 2015. Methods Enzymol. 554: 189-200. PMID: 25725523
- In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals. | Moeller, BM., et al. 2017. Toxicol Lett. 274: 64-68. PMID: 28412453
- Methionine restriction leads to hyperhomocysteinemia and alters hepatic H2S production capacity in Fischer-344 rats. | Tamanna, N., et al. 2018. Mech Ageing Dev. 176: 9-18. PMID: 30367932
- Mercaptans decrease selenium-dependent glutathione peroxidase activity in the chick. | Mercurio, SD. and Combs, GF. 1987. J Nutr. 117: 880-5. PMID: 3585541
- 3-Mercaptopyruvate sulfurtransferase (EC 2.8.1.2): a simple assay adapted to human blood cells. | Valentine, WN. and Frankenfeld, JK. 1974. Clin Chim Acta. 51: 205-10. PMID: 4828222
- Electron paramagnetic resonance evidence for a cysteine-based radical in pyruvate formate-lyase inactivated with mercaptopyruvate. | Parast, CV., et al. 1995. Biochemistry. 34: 5712-7. PMID: 7727431
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sodium mercaptopyruvate, 100 mg | sc-236908 | 100 mg | $112.00 |