Rhamnetin (CAS 90-19-7)
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Rhamnetin is a flavonoid compound that functions as an antioxidant in experimental applications. It exerts its mechanism of action by scavenging free radicals and inhibiting oxidative stress at the molecular level. Rhamnetin also demonstrates anti-inflammatory properties by modulating the activity of pro-inflammatory enzymes and cytokines. It inhibits the proliferation of certain cancer cells by inducing apoptosis and cell cycle arrest. Rhamnetin interacts with various signaling pathways involved in oxidative stress and inflammation, thereby exerting its antioxidant and anti-inflammatory effects. Its ability to modulate these pathways makes it a compound for studying the molecular mechanisms underlying oxidative stress, inflammation, and cancer cell proliferation in experimental models.
Rhamnetin (CAS 90-19-7) References
- Optimization of rhamnetin production in Escherichia coli. | Sung, SH., et al. 2011. J Microbiol Biotechnol. 21: 854-7. PMID: 21876376
- Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. | Kim, YJ. 2013. Biol Pharm Bull. 36: 1341-7. PMID: 23739488
- Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. | Kang, J., et al. 2013. J Biol Chem. 288: 27343-27357. PMID: 23902763
- Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H₂O₂-induced apoptosis. | Park, ES., et al. 2014. J Ethnopharmacol. 153: 552-60. PMID: 24607510
- Cytoprotective effect of rhamnetin on miconazole-induced H9c2 cell damage. | Lee, KP., et al. 2015. Nutr Res Pract. 9: 586-91. PMID: 26634046
- Rhamnetin induces apoptosis in human breast cancer cells via the miR-34a/Notch-1 signaling pathway. | Lan, L., et al. 2019. Oncol Lett. 17: 676-682. PMID: 30655816
- Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR-148a/PXR axis. | Li, B., et al. 2021. Food Funct. 12: 2404-2417. PMID: 33570057
- Rhamnetin: a review of its pharmacology and toxicity. | Medeiros, DL., et al. 2022. J Pharm Pharmacol. 74: 793-799. PMID: 34931654
- RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2'-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION. | Rowaiye, AB., et al. 2022. Afr J Infect Dis. 16: 80-96. PMID: 35582066
- Rhamnetin, a Natural Flavonoid, Ameliorates Organ Damage in a Mouse Model of Carbapenem-Resistant Acinetobacter baumannii-Induced Sepsis. | Lee, H., et al. 2022. Int J Mol Sci. 23: PMID: 36361685
- Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro. | Shatta, MA., et al. 2023. Mol Cell Biochem. 478: 1689-1704. PMID: 36495373
- Investigation of the effect of rhamnetin on mice injected with solid and ehrlich ascites tumor. | Bozkurt, Ö., et al. 2023. Med Oncol. 40: 124. PMID: 36947317
- Rhamnetin 3-p-coumaroylrhamninoside from Rhamnus petiolaris. | Ozipek, M., et al. 1994. Phytochemistry. 37: 249-53. PMID: 7765615
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rhamnetin, 1 mg | sc-236668 | 1 mg | $83.00 |