Date published: 2025-12-1

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Protocatechuic acid ethyl ester (CAS 3943-89-3)

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Alternate Names:
Ethyl 3,4-dihydroxybenzoate
Application:
CAS Number:
3943-89-3
Purity:
≥98%
Molecular Weight:
182.17
Molecular Formula:
C9H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Protocatechuic acid ethyl ester, a derivative of protocatechuic acid, exhibits promising bioactivity and has garnered attention in scientific research for its diverse potential applications. This compound is recognized for its antioxidant properties, attributed to its ability to scavenge free radicals and inhibit oxidative stress-induced damage. In addition to its antioxidant effects, protocatechuic acid ethyl ester has demonstrated anti-inflammatory activity by modulating inflammatory mediators and pathways, suggesting its potential utility in inflammatory conditions. Moreover, research has revealed its neuroprotective properties, with studies highlighting its ability to mitigate neuronal damage and enhance cognitive function in experimental models of neurodegenerative diseases. Furthermore, protocatechuic acid ethyl ester has shown antimicrobial activity against various pathogens, including bacteria and fungi, indicating its potential as a natural antimicrobial agent. Its multifaceted bioactivity underscores its significance in biomedical research, where it is investigated for its potential in oxidative stress-related disorders, inflammation-driven pathologies, neurodegenerative diseases, and infectious conditions. Additionally, ongoing studies explore its pharmacokinetics, metabolism, and safety profile to further explain its applicability and optimize its development as a potential agent or dietary supplement.


Protocatechuic acid ethyl ester (CAS 3943-89-3) References

  1. Polyhydroxybenzoates inhibit ascorbic acid activation of mitochondrial glycerol-3-phosphate dehydrogenase: implications for glucose metabolism and insulin secretion.  |  Wells, WW., et al. 2001. J Biol Chem. 276: 2404-10. PMID: 11060297
  2. Silymarin improves the behavioural, biochemical and histoarchitecture alterations in focal ischemic rats: a comparative evaluation with piracetam and protocatachuic acid.  |  Muley, MM., et al. 2012. Pharmacol Biochem Behav. 102: 286-93. PMID: 22584042
  3. Chemical constituents of Spatholobus suberectus.  |  Tang, RN., et al. 2012. Chin J Nat Med. 10: 32-5. PMID: 23302527
  4. Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model.  |  Muley, MM., et al. 2013. Life Sci. 93: 51-57. PMID: 23743171
  5. In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts.  |  Kang, SN., et al. 2014. Nutrients. 6: 1737-51. PMID: 24763116
  6. Antibacterial Activity of Protocatechuic Acid Ethyl Ester on Staphylococcus aureus Clinical Strains Alone and in Combination with Antistaphylococcal Drugs.  |  Miklasińska, M., et al. 2015. Molecules. 20: 13536-49. PMID: 26213908
  7. Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice.  |  Thakare, VN., et al. 2017. Metab Brain Dis. 32: 401-413. PMID: 27785705
  8. The Hypoxia Mimetic Protocatechuic Acid Ethyl Ester Inhibits Synaptic Signaling and Plasticity in the Rat Hippocampus.  |  Lanigan, SM. and O'Connor, JJ. 2018. Neuroscience. 369: 168-182. PMID: 29129792
  9. Effect of Protocatechuic Acid Ethyl Ester on Biomembrane Models: Multilamellar Vesicles and Monolayers.  |  Torrisi, C., et al. 2022. Membranes (Basel). 12: PMID: 35323757
  10. The Array of Antibacterial Action of Protocatechuic Acid Ethyl Ester and Erythromycin on Staphylococcal Strains.  |  Miklasińska-Majdanik, M., et al. 2022. Antibiotics (Basel). 11: PMID: 35884102

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Protocatechuic acid ethyl ester, 5 g

sc-236496
5 g
$32.00