Nivalenol (CAS 23282-20-4)
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Nivalenol is a cytotoxic trichothecene mycotoxin that has been found in a variety of grains and other plant-based foods. It decreases cell proliferation and also displays pro-apoptotic activity. Nivalenol is known to bind to a variety of cellular proteins, including the aryl hydrocarbon receptor (AhR). This binding triggers a cascade of events that result in the activation of a variety of genes involved in the metabolism of xenobiotics and other cellular processes. Nivalenol also interferes with the activity of enzymes involved in the synthesis and metabolism of proteins, lipids, and carbohydrates, as well as a variety of hormones and neurotransmitters. It has been studied extensively in scientific research, primarily in the areas of food safety, toxicology, and human and animal health. It has been used as a model system to study the toxic effects of mycotoxins, and to evaluate the efficacy of detoxification and decontamination methods. It may act to be active in vitro (EC50 = 0.96 muM) andin vivo.
Nivalenol (CAS 23282-20-4) References
- Identification of deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae by using PCR. | Lee, T., et al. 2001. Appl Environ Microbiol. 67: 2966-72. PMID: 11425709
- Stability of the fusarium mycotoxins nivalenol, deoxynivalenol and zearalenone in ground maize under typical cooking environments. | Lauren, DR. and Smith, WA. 2001. Food Addit Contam. 18: 1011-6. PMID: 11665729
- Tri13 and Tri7 determine deoxynivalenol- and nivalenol-producing chemotypes of Gibberella zeae. | Lee, T., et al. 2002. Appl Environ Microbiol. 68: 2148-54. PMID: 11976083
- Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials. | Avantaggiato, G., et al. 2004. Food Chem Toxicol. 42: 817-24. PMID: 15046828
- A practical method for measuring deoxynivalenol, nivalenol, and T-2 + HT-2 toxin in foods by an enzyme-linked immunosorbent assay using monoclonal antibodies. | Yoshizawa, T., et al. 2004. Biosci Biotechnol Biochem. 68: 2076-85. PMID: 15502352
- Fusarium poae and Fusarium crookwellense, Fungi Responsible for the Natural Occurrence of Nivalenol in Hokkaido. | Sugiura, Y., et al. 1993. Appl Environ Microbiol. 59: 3334-8. PMID: 16349068
- Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation. | Luongo, D., et al. 2008. Toxicon. 52: 156-62. PMID: 18620720
- Genetic Fusarium chemotyping as a useful tool for predicting nivalenol contamination in winter wheat. | Pasquali, M., et al. 2010. Int J Food Microbiol. 137: 246-53. PMID: 20004994
- Occurrence of Gibberella zeae strains that produce both nivalenol and deoxynivalenol. | Sugiura, Y., et al. 1990. Appl Environ Microbiol. 56: 3047-51. PMID: 2285316
- Individual and combined cytotoxic effects of Fusarium toxins (deoxynivalenol, nivalenol, zearalenone and fumonisins B1) on swine jejunal epithelial cells. | Wan, LY., et al. 2013. Food Chem Toxicol. 57: 276-83. PMID: 23562706
- Regional differences in species composition and toxigenic potential among Fusarium head blight isolates from Uruguay indicate a risk of nivalenol contamination in new wheat production areas. | Umpiérrez-Failache, M., et al. 2013. Int J Food Microbiol. 166: 135-40. PMID: 23856007
- Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells. | Alassane-Kpembi, I., et al. 2015. Arch Toxicol. 89: 1337-46. PMID: 25033990
- Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs. | Gerez, JR., et al. 2015. Exp Toxicol Pathol. 67: 89-98. PMID: 25467749
- The acute and chronic toxicities of nivalenol in mice. | Ryu, JC., et al. 1988. Fundam Appl Toxicol. 11: 38-47. PMID: 3209016
- Natural co-occurrence of aflatoxins and Fusarium mycotoxins (fumonisins, deoxynivalenol, nivalenol and zearalenone) in corn from Indonesia. | Ali, N., et al. 1998. Food Addit Contam. 15: 377-84. PMID: 9764205
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nivalenol, 5 mg | sc-236183 | 5 mg | $662.00 |