Date published: 2025-11-2

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Dicyclohexyl phthalate (CAS 84-61-7)

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CAS Number:
84-61-7
Molecular Weight:
330.42
Molecular Formula:
C20H26O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dicyclohexyl Phthalate is a versatile chemical compound used for sample preparation for analytical testing. It is a phthalate ester used as a plasticizer and also found in cosmetic products. Additionally, the release of dibutyl phthalates from plastics into wastewater can induce adverse effects on organisms that rely on the water. Potentially effects can lead to alterations in receptor binding and molecular docking analysis.


Dicyclohexyl phthalate (CAS 84-61-7) References

  1. Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl phthalate administered orally to rats.  |  Saillenfait, AM., et al. 2009. J Appl Toxicol. 29: 510-21. PMID: 19391110
  2. Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats.  |  Yamasaki, K., et al. 2009. Toxicol Lett. 189: 14-20. PMID: 19410640
  3. An indirect competitive fluorescence immunoassay for determination of dicyclohexyl phthalate in water samples.  |  Zhang, M. and Sheng, Y. 2010. J Fluoresc. 20: 1167-73. PMID: 20390441
  4. In utero exposure to dicyclohexyl and di-n-hexyl phthalate possess genotoxic effects on testicular cells of male rats after birth in the comet and TUNEL assays.  |  Ahbab, MA., et al. 2014. Hum Exp Toxicol. 33: 230-9. PMID: 23836838
  5. Influence of in utero di-n-hexyl phthalate and dicyclohexyl phthalate on fetal testicular development in rats.  |  Aydoğan Ahbab, M. and Barlas, N. 2015. Toxicol Lett. 233: 125-37. PMID: 25637754
  6. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells.  |  Li, X., et al. 2016. Int J Environ Res Public Health. 13: PMID: 26907321
  7. Response to the Svingen Comments on Li et al. Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health, 2016, 13, 246.  |  Li, X., et al. 2016. Int J Environ Res Public Health. 13: PMID: 27231929
  8. Inhibitory modulation of human estrogen receptor α and β activities by dicyclohexyl phthalate in human breast cancer cell lines.  |  Okazaki, H., et al. 2017. J Toxicol Sci. 42: 417-425. PMID: 28717100
  9. Comparative developmental toxicity evaluation of di- n-hexyl phthalate and dicyclohexyl phthalate in rats.  |  Ahbab, MA., et al. 2017. Toxicol Ind Health. 33: 696-716. PMID: 28854868
  10. Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis.  |  Lv, Y., et al. 2019. Toxicology. 411: 60-70. PMID: 30391266
  11. Identification of dicyclohexyl phthalate as a glucocorticoid receptor antagonist by molecular docking and multiple in vitro methods.  |  Leng, Y., et al. 2021. Mol Biol Rep. 48: 3145-3154. PMID: 33881729
  12. Comprehensive insights into the interactions of dicyclohexyl phthalate and its metabolite to human serum albumin.  |  Lv, X., et al. 2021. Food Chem Toxicol. 155: 112407. PMID: 34273427
  13. Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.  |  Sui, Y., et al. 2021. Environ Health Perspect. 129: 127001. PMID: 34851150
  14. Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice.  |  Liu, J., et al. 2022. Cells. 11: PMID: 35406689
  15. Effects of the in-utero dicyclohexyl phthalate and di-n-hexyl phthalate administration on the oxidative stress-induced histopathological changes in the rat liver tissue correlated with serum biochemistry and hematological parameters.  |  Aydemir, D., et al. 2023. Front Endocrinol (Lausanne). 14: 1128202. PMID: 37274322

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dicyclohexyl phthalate, 250 mg

sc-234608
250 mg
$41.00