Betulin (CAS 473-98-3)
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Betulin is a triterpene with a pentacyclic ring structure and hydroxyl groups in positions C3 and C28. Studies indicate that Betulin can effect intracellular signaling in ethanol-induced liver cells via inhibiting ROS, TNFalpha and TNFbeta. In human cancer cells Betulin can induce mitochondrial cytochrome C release in human cancer cells, which results in apoptosis. Alternate studies on mice show that Betulin binds to melanocortin receptors and antagonizes the release of cAMP generation in mouse melanoma cells. Furthermore, Betulin has protective effects against cadmium induced apoptosis in human hepatoma cell lines. This occurs by inhibiting the activation of ROS, blocking Bid activation and suppressing the mitochondrial pathway.
Betulin (CAS 473-98-3) References
- Protection of betulin against cadmium-induced apoptosis in hepatoma cells. | Oh, SH., et al. 2006. Toxicology. 220: 1-12. PMID: 16436312
- Betulin binds to melanocortin receptors and antagonizes alpha-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells. | Muceniece, R., et al. 2007. Cell Biochem Funct. 25: 591-6. PMID: 17605140
- Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells. | Li, Y., et al. 2010. Mol Carcinog. 49: 630-40. PMID: 20564340
- Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. | Tang, JJ., et al. 2011. Cell Metab. 13: 44-56. PMID: 21195348
- Betulin-betulinic acid natural product based analogs as anti-cancer agents. | Jonnalagadda, SC., et al. 2013. Anticancer Agents Med Chem. 13: 1477-99. PMID: 23848199
- Comprehensive review on betulin as a potent anticancer agent. | Król, SK., et al. 2015. Biomed Res Int. 2015: 584189. PMID: 25866796
- Betulin and its derivatives as novel compounds with different pharmacological effects. | Amiri, S., et al. 2020. Biotechnol Adv. 38: 107409. PMID: 31220568
- Betulin Inhibits Lung Metastasis by Inducing Cell Cycle Arrest, Autophagy, and Apoptosis of Metastatic Colorectal Cancer Cells. | Han, YH., et al. 2019. Nutrients. 12: PMID: 31887988
- Betulin attenuates pneumolysin-induced cell injury and DNA damage. | Qi, Z., et al. 2021. J Appl Microbiol. 130: 843-851. PMID: 32621771
- Betulin Attenuates TGF-β1- and PGE2-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice. | Ogasawara, M., et al. 2022. Biol Pharm Bull. 45: 339-353. PMID: 35228400
- Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides. | Kozubek, M., et al. 2022. Steroids. 182: 109014. PMID: 35314417
- Betulin, Synthesized by PpCYP716A1, Is a Key Endogenous Defensive Metabolite of Peach against Aphids. | Wang, J., et al. 2022. J Agric Food Chem. 70: 12865-12877. PMID: 36173088
- Highly Branched Betulin Based Polyanhydrides for Self-Assembled Micellar Nanoparticles Formulation. | Niewolik, D., et al. 2022. Int J Mol Sci. 23: PMID: 36232762
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Betulin, 1 g | sc-234016 | 1 g | $102.00 |