(+)-Menthol (CAS 15356-60-2)
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(+)-Menthol is a compound that functions as a TRPM8 receptor agonist, activating this specific receptor in sensory neurons. This activation leads to the sensation of cooling or analgesia, making it useful in experimental applications where these effects are desired. At the molecular level, (+)-Menthol interacts with the TRPM8 receptor, causing a conformational change that allows for the influx of calcium ions into the cell. This influx of calcium ions then triggers downstream signaling pathways, ultimately leading to the perception of cooling or pain relief. (+)-Menthol′s mechanism of action as a TRPM8 receptor agonist can be utilized to study sensory perception, pain pathways, and the development of novel analgesic compounds. Its specific interaction with the TRPM8 receptor may be useful for investigating the molecular mechanisms underlying cold sensation and pain modulation.
(+)-Menthol (CAS 15356-60-2) References
- Fragrance material review on d-menthol. | Bhatia, SP., et al. 2008. Food Chem Toxicol. 46 Suppl 11: S215-7. PMID: 18640220
- Different effects of l- and d-menthol on the microstructure of ceramide 5/cholesterol/palmitic acid bilayers. | Watanabe, H., et al. 2010. Int J Pharm. 402: 146-52. PMID: 20932885
- The stereoisomers of menthol in selected tobacco products. A brief report. | Chen, C., et al. 2011. Nicotine Tob Res. 13: 741-5. PMID: 21447840
- Effects of d-menthol stress on the growth of and microcystin release by the freshwater cyanobacterium Microcystis aeruginosa FACHB-905. | Hu, X., et al. 2014. Chemosphere. 113: 30-5. PMID: 25065786
- Enantioselective recognition of menthol by mouse odorant receptors. | Takai, Y. and Touhara, K. 2015. Biosci Biotechnol Biochem. 79: 1980-6. PMID: 26248186
- Chirality-Dependent Interaction of d- and l-Menthol with Biomembrane Models. | Gusain, P., et al. 2017. Membranes (Basel). 7: PMID: 29244740
- Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL. | Kozlovich, S., et al. 2019. Drug Metab Dispos. 47: 1388-1396. PMID: 31578206
- Enantioselective three-component aminomethylation of α-diazo ketones with alcohols and 1,3,5-triazines. | Che, J., et al. 2020. Nat Commun. 11: 1511. PMID: 32251288
- The effects of D and L isomers of menthol upon nasal sensation of airflow. | Eccles, R., et al. 1988. J Laryngol Otol. 102: 506-8. PMID: 3397650
- Beyond Ca2+ signalling: the role of TRPV3 in the transport of NH4. | Liebe, H., et al. 2021. Pflugers Arch. 473: 1859-1884. PMID: 34664138
- Engineering a Bacillus subtilis esterase for selective hydrolysis of d, l-menthyl acetate in an organic solvent-free system. | Qiao, J., et al. 2023. RSC Adv. 13: 10468-10475. PMID: 37021103
- New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties. | Ma, P., et al. 2023. Pharmaceutics. 15: PMID: 37111588
- The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay). | Hartmann, A. and Speit, G. 1997. Toxicol Lett. 90: 183-8. PMID: 9067486
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(+)-Menthol, 10 g | sc-229843 | 10 g | $71.00 |