Date published: 2025-11-7

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Picolinafen (CAS 137641-05-5)

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Alternate Names:
N-(4-Fluorophenyl)-6-(α,α,α-trifluoro-m-tolyloxy)picolinamide
CAS Number:
137641-05-5
Molecular Weight:
376.30
Molecular Formula:
C19H12F4N2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Picolinafen is an herbicide, effectively inhibiting plant growth by targeting the enzyme acylation reaction essential for fatty acid synthesis within plant cells. Its effectiveness extends to combatting weeds like Picolinic acid and Triazolopyrimidine. Picolinafen has been found to be synergistically with other herbicides, notably Benzalkonium chloride. In vitro studies have revealed film-forming polymer properties capable of creating a protective coating on plants. Furthermore, kinetic energy analysis has confirmed its stability in water.


Picolinafen (CAS 137641-05-5) References

  1. Characterization of a higher plant herbicide-resistant phytoene desaturase and its use as a selectable marker.  |  Arias, RS., et al. 2006. Plant Biotechnol J. 4: 263-73. PMID: 17177802
  2. Cross-resistance to diflufenican and picolinafen and its inheritance in oriental mustard (Sisymbrium orientale L.).  |  Dang, HT., et al. 2019. Pest Manag Sci. 75: 195-203. PMID: 29799165
  3. Trace organic chemical pollutants from the lake waters of San Pablo City, Philippines by targeted and non-targeted analysis.  |  Dimzon, IKD., et al. 2018. Sci Total Environ. 639: 588-595. PMID: 29800852
  4. No apparent fitness costs associated with phytoene desaturase mutations conferred resistance to diflufenican and picolinafen in oriental mustard (Sisymbrium orientale L.).  |  Dang, HT., et al. 2019. Pestic Biochem Physiol. 155: 51-57. PMID: 30857627
  5. Evaluation of confirmatory data following the Article 12 MRL review for picolinafen.  |  , ., et al. 2018. EFSA J. 16: e05489. PMID: 32625767
  6. Establishment of cumulative assessment groups of pesticides for their effects on the thyroid.  |  , ., et al. 2019. EFSA J. 17: e05801. PMID: 32626429
  7. Picolinafen exerts developmental toxicity via the suppression of oxidative stress and angiogenesis in zebrafish embryos.  |  Lee, JY., et al. 2021. Pestic Biochem Physiol. 171: 104734. PMID: 33357556
  8. In Silico Structure-Guided Optimization and Molecular Simulation Studies of 3-Phenoxy-4-(3-trifluoromethylphenyl)pyridazines as Potent Phytoene Desaturase Inhibitors.  |  Yang, L., et al. 2021. Molecules. 26: PMID: 34834071
  9. Umpolung Synthesis of Pyridyl Ethers by BiV -Mediated O-Arylation of Pyridones.  |  Ruffell, K., et al. 2022. Angew Chem Int Ed Engl. 61: e202212873. PMID: 36251336
  10. Advancement of Phenoxypyridine as an Active Scaffold for Pesticides.  |  Liu, Y., et al. 2022. Molecules. 27: PMID: 36296394
  11. Picolinafen exposure induces ROS accumulation and calcium depletion, leading to apoptosis in porcine embryonic trophectoderm and uterine luminal epithelial cells during the peri-implantation period.  |  Park, W., et al. 2023. Theriogenology. 201: 12-23. PMID: 36809717

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Picolinafen, 100 mg

sc-228945
100 mg
$112.00

Picolinafen, 1 g

sc-228945A
1 g
$670.00

Picolinafen, 3 g

sc-228945B
3 g
$1950.00