Date published: 2025-11-20

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Homovanillyl alcohol (CAS 2380-78-1)

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Alternate Names:
Vanillylmethanol
Application:
Homovanillyl alcohol is a key component of Queen mandibular pheromone
CAS Number:
2380-78-1
Molecular Weight:
168.19
Molecular Formula:
C9H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Homovanillyl alcohol (HVA), also referred to as 4-hydroxy-3-methoxybenzyl alcohol or 4-hydroxy-3-methoxybenzyl alcoholdehyde, is a naturally occurring phenolic compound present in plants, fungi, and bacteria. This versatile substance has garnered significant attention due to its biochemical and physiological properties. It finds extensive application in scientific research, particularly in investigating the effects of dietary compounds on the body and understanding the metabolism, pharmacokinetics, and toxicology of xenobiotics.


Homovanillyl alcohol (CAS 2380-78-1) References

  1. Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol.  |  Bernini, R., et al. 2008. J Agric Food Chem. 56: 8897-904. PMID: 18771272
  2. Dopamine receptor activation by honey bee queen pheromone.  |  Beggs, KT. and Mercer, AR. 2009. Curr Biol. 19: 1206-9. PMID: 19523830
  3. Protective activity of hydroxytyrosol metabolites on erythrocyte oxidative-induced hemolysis.  |  Paiva-Martins, F., et al. 2013. J Agric Food Chem. 61: 6636-42. PMID: 23777263
  4. A Convenient Synthesis of Hydroxytyrosol Monosulfate Metabolites.  |  Gomes, VP., et al. 2015. J Agric Food Chem. 63: 9565-71. PMID: 26492463
  5. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea).  |  Kano, S., et al. 2016. J Nutr Metab. 2016: 9104208. PMID: 26904279
  6. Protective effect of homovanillyl alcohol on cardiovascular disease and total mortality: virgin olive oil, wine, and catechol-methylation.  |  De la Torre, R., et al. 2017. Am J Clin Nutr. 105: 1297-1304. PMID: 28446500
  7. Synthesis of Lipophilic Esters of Tyrosol, Homovanillyl Alcohol and Hydroxytyrosol.  |  Bernini, R., et al. 2019. Antioxidants (Basel). 8: PMID: 31197081
  8. Protective effect of olive oil polyphenol phase II sulfate conjugates on erythrocyte oxidative-induced hemolysis.  |  Fernandes, S., et al. 2020. Food Funct. 11: 8670-8679. PMID: 32939526
  9. The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models.  |  Brito, C., et al. 2021. Molecules. 26: PMID: 33430068
  10. Solid-phase synthesis of curcumin mimics and their anticancer activity against human pancreatic, prostate, and colorectal cancer cell lines.  |  Romanucci, V., et al. 2021. Bioorg Med Chem. 42: 116249. PMID: 34126286
  11. A novel combined analytical UV and MS approach for the quantification of oleuropein metabolites in human biological samples when authentic standards are not available.  |  Polia, F., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1210: 123457. PMID: 36150306
  12. Indirect characterizations of mOR-EG: Modeling analysis of five concentration-olfactory response curves via an advanced monolayer adsorption model.  |  Ben Khemis, I., et al. 2022. Int J Biol Macromol. 222: 1277-1286. PMID: 36195222
  13. Chemoenzymatic Cascade Reaction for the Valorization of the Lignin Depolymerization Product G-C2-Dioxolane Phenol.  |  Terholsen, H., et al. 2023. ChemSusChem. 16: e202300168. PMID: 36826410

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Homovanillyl alcohol, 2.5 g

sc-228312
2.5 g
$158.00