Molecular structure of (−)-α-Bisabolol, CAS Number: 23089-26-1
(−)-α-Bisabolol (CAS 23089-26-1)
Alternate Names:
(−)-6-Methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (−)-alpha-Bisabolol; Levomenol
CAS Number:
23089-26-1
Purity:
≥93%
Molecular Weight:
222.37
Molecular Formula:
C15H26O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(−)-α-Bisabolol is a monocyclic sesquiterpene alcohol found in the essential oil of different plants like Vanillosmopsis erythropappa and Matricaria chamomilla. It has potential applications in the clinical and cosmetic industries due to its anti-inflammatory, anti-irritant, and antimicrobial properties. It also shows effective action against malignant tumor cells. (−)-α-Bisabolol inhibits the growth of L. amazonensis promastigotes and amastigotes (IC50s = 8.07 and 4.29 μg/ml, respectively). It also reduces the growth of L. infantum and L. donovani amastigotes (IC50s = 56.9 and 39.4 μM, respectively) with a cytotoxic concentration (CC50) value of greater than 1,000 μM in L929 cells.
(−)-α-Bisabolol (CAS 23089-26-1) References
- Phase solubility studies of pure (-)-alpha-bisabolol and camomile essential oil with beta-cyclodextrin. | Waleczek, KJ., et al. 2003. Eur J Pharm Biopharm. 55: 247-51. PMID: 12637105
- Activity of (-)alpha-bisabolol against Leishmania infantum promastigotes. | Morales-Yuste, M., et al. 2010. Phytomedicine. 17: 279-81. PMID: 19577452
- Gastroprotection of (-)-alpha-bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms. | Moura Rocha, NF., et al. 2010. Fundam Clin Pharmacol. 24: 63-71. PMID: 19663933
- Evaluation of the sesquiterpene (-)-alpha-bisabolol as a novel peripheral nervous blocker. | Alves, Ade M., et al. 2010. Neurosci Lett. 472: 11-5. PMID: 20105451
- Antitumor activity of (-)-alpha-bisabolol-based thiosemicarbazones against human tumor cell lines. | da Silva, AP., et al. 2010. Eur J Med Chem. 45: 2987-93. PMID: 20413188
- (-)-α-Bisabolol attenuates visceral nociception and inflammation in mice. | Leite, Gde O., et al. 2011. Fitoterapia. 82: 208-11. PMID: 20875845
- Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. | Kim, S., et al. 2011. Food Chem Toxicol. 49: 2580-5. PMID: 21771629
- Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents. | Rocha, NF., et al. 2011. Naunyn Schmiedebergs Arch Pharmacol. 384: 525-33. PMID: 21870032
- (-)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration. | Rocha, NF., et al. 2011. Eur J Pharm Sci. 44: 455-61. PMID: 21924353
- α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. | Maurya, AK., et al. 2014. Curr Pharm Biotechnol. 15: 173-81. PMID: 24894548
- In vitro evaluation of (-)α-bisabolol as a promising agent against Leishmania amazonensis. | Rottini, MM., et al. 2015. Exp Parasitol. 148: 66-72. PMID: 25448354
- (-)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis. | Corpas-López, V., et al. 2015. J Nat Prod. 78: 1202-7. PMID: 26076227
- Fermentative production and direct extraction of (-)-α-bisabolol in metabolically engineered Escherichia coli. | Han, GH., et al. 2016. Microb Cell Fact. 15: 185. PMID: 27825357
- Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil. | Hajaji, S., et al. 2018. Parasitol Res. 117: 2855-2867. PMID: 29955971
- Production of (-)-α-bisabolol in metabolically engineered Saccharomyces cerevisiae. | Kim, TY., et al. 2021. J Biotechnol. 340: 13-21. PMID: 34391805
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(−)-α-Bisabolol, 5 ml | sc-227155 | 5 ml | $64.00 |