Date published: 2026-2-24

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Diclazuril (CAS 101831-37-2)

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Application:
Diclazuril is a useful biochemical for proteomics research
CAS Number:
101831-37-2
Molecular Weight:
407.64
Molecular Formula:
C17H9Cl3N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diclazuril is a compound that functions as a potent coccidiostat. It exerts its mechanism of action by targeting and inhibiting the enzyme dihydrofolate reductase in the protozoan parasite. This inhibition disrupts the folate metabolism of the parasite, leading to the depletion of nucleotides required for DNA synthesis and cell division. As a result, diclazuril effectively prevents the proliferation and spread of coccidian parasites within the host organism. This mechanism of action occurs at the molecular level, interfering with the vital metabolic processes of the parasite without affecting the host. By disrupting the parasite′s ability to reproduce and cause infection, diclazuril plays a role in experimental studies aimed at understanding and controlling coccidiosis in various animal species.


Diclazuril (CAS 101831-37-2) References

  1. Diclazuril in the horse: its identification and detection and preliminary pharmacokinetics.  |  Dirikolu, L., et al. 1999. J Vet Pharmacol Ther. 22: 374-9. PMID: 10651466
  2. Diclazuril Protects against Maternal Gastrointestinal Syndrome and Congenital Toxoplasmosis.  |  Oz, HS. and Tobin, T. 2014. Int J Clin Med. 5: 93-101. PMID: 24851194
  3. Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days.  |  Hunyadi, L., et al. 2018. Vet J. 242: 74-76. PMID: 30503548
  4. Protective potential of diclazuril-treated oocysts against coccidiosis in layer chicks.  |  El-Ashram, S., et al. 2019. Vet Parasitol. 273: 105-111. PMID: 31473449
  5. HPLC semi-preparative separation of diclazuril enantiomers and racemization in solution.  |  Huang, Z., et al. 2020. J Sep Sci. 43: 1240-1247. PMID: 31909564
  6. Efficacy of probiotic Enterococcus faecium in combination with diclazuril against coccidiosis in experimentally infected broilers.  |  El-Sawah, AA., et al. 2020. J Appl Microbiol. 129: 1020-1028. PMID: 32364304
  7. Effects of diclazuril on the expression of enolase in second-generation merozoites of Eimeria tenella.  |  Zhou, BH., et al. 2020. Poult Sci. 99: 6402-6409. PMID: 33248555
  8. Diclazuril Inhibits Biofilm Formation and Hemolysis of Staphylococcus aureus.  |  Zheng, J., et al. 2021. ACS Infect Dis. 7: 1690-1701. PMID: 34019393
  9. Interactions of diclazuril enantiomers with serum albumins: Multi-spectroscopic and molecular docking approaches.  |  Chen, R., et al. 2022. J Mol Recognit. 35: e2948. PMID: 35094438
  10. Plasma concentrations of diclazuril following oral administration of diclazuril and diclazuril sodium salt to cattle.  |  Dirikolu, L., et al. 2022. J Vet Pharmacol Ther. 45: 392-401. PMID: 35488857
  11. Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model.  |  Ahmadi, P., et al. 2022. J Vet Med Sci. 84: 1345-1351. PMID: 35922919
  12. Tetrabromobisphenol A and Diclazuril Evoke Tissue-Specific Changes of Thyroid Hormone Signaling in Male Thyroid Hormone Action Indicator Mice.  |  Sinkó, R., et al. 2022. Int J Mol Sci. 23: PMID: 36499108
  13. Diclazuril-induced expression of CDK-related kinase 2 in the second-generation merozoites of Eimeria tenella.  |  Zhou, BH., et al. 2023. Mol Biochem Parasitol. 255: 111575. PMID: 37302489

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diclazuril, 100 mg

sc-223937
100 mg
$115.00