Molecular structure of Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata, CAS Number: 67416-61-9
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata (CAS 67416-61-9)
Alternate Names:
3-O-Acetyl-11-keto-β-Boswellic Acid
Application:
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata is a 5-LO and topo I and II inhibitor
CAS Number:
67416-61-9
Purity:
≥98%
Molecular Weight:
512.72
Molecular Formula:
C32H48O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata is a potent non-redox, noncompetitive 5-LO (5-lipoxygenase) and Topo I and II inhibitor leading to apoptosis. Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata is 10-times more potent than 3-O-acetyl-β-boswellic acid (sc-202885). In addition, Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata shows antitumor and anti-inflammatory activities.
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata (CAS 67416-61-9) References
- Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. | Altmann, A., et al. 2002. Biochem Biophys Res Commun. 290: 185-90. PMID: 11779151
- Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. | Altmann, A., et al. 2004. Br J Pharmacol. 141: 223-32. PMID: 14691050
- Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo. | Syrovets, T., et al. 2005. J Biol Chem. 280: 6170-80. PMID: 15576374
- In silico analysis of aqueous root extract of Rotula aquatica Lour for docking analysis of the compound 3-O-acetyl-11-keto-β-boswellic acid contents. | Vijayakumari, B., et al. 2016. Springerplus. 5: 1486. PMID: 27652060
- Ring A-modified Derivatives from the Natural Triterpene 3-O-acetyl-11-keto-β-Boswellic Acid and their Cytotoxic Activity. | Li, T., et al. 2017. Anticancer Agents Med Chem. 17: 1153-1167. PMID: 27928954
- Understanding the role of 3-O-Acetyl-11-keto-β-boswellic acid in conditions of oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity. | Kumar, M., et al. 2017. Food Chem Toxicol. 109: 871-878. PMID: 28363852
- The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation. | Ranzato, E., et al. 2017. Phytomedicine. 36: 176-182. PMID: 29157812
- 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. | Li, W., et al. 2018. J Exp Clin Cancer Res. 37: 132. PMID: 29970196
- 3-O-Acetyl-11-keto- β -boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma. | Li, W., et al. 2020. Acta Pharm Sin B. 10: 301-312. PMID: 32082975
- A Validated LC-MS/MS Method for Simultaneous Determination of 3-O-Acetyl-11-Keto-β-Boswellic Acid (AKBA) and its Active Metabolite Acetyl-11-Hydroxy-β-Boswellic Acid (Ac-11-OH-BA) in Rat Plasma: Application to a Pharmacokinetic Study. | Sharma, T. and Jana, S. 2020. J Chromatogr Sci. 58: 485-493. PMID: 32134105
- 3-O-Acetyl-11-keto-β-boswellic acid ameliorates chronic unpredictable mild stress induced HPA axis dysregulation in relation with glutamate/GABA aberration in depressive rats. | Gunasekaran, V., et al. 2021. Clin Exp Pharmacol Physiol. 48: 1633-1641. PMID: 34343356
- 3-O-Acetyl-11-keto-β-boswellic acid ameliorates acquired, consolidated and recognitive memory deficits through the regulation of hippocampal PPAR γ, MMP9 and MMP2 genes in dementia model. | Gunasekaran, V., et al. 2021. Heliyon. 7: e08523. PMID: 34926858
- The Biological Activity of 3-O-Acetyl-11-keto-β-Boswellic Acid in Nervous System Diseases. | Gong, Y., et al. 2022. Neuromolecular Med. 24: 374-384. PMID: 35303275
- Synthesis of 3-O-Acetyl-11-keto-β-boswellic Acid (AKBA)-Derived Amides and Their Mitochondria-Targeted Antitumor Activities. | Li, C., et al. 2022. ACS Omega. 7: 9853-9866. PMID: 35350335
Inhibitor of:
5-LO, Topo I, and Topo II.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata, 5 mg | sc-221208 | 5 mg | $180.00 |