Molecular structure of Helenalin, CAS Number: 6754-13-8
Helenalin (CAS 6754-13-8)
See product citations (8)
Alternate Names:
NF-κB inhibitor
Application:
Helenalin is an inhibitor of the transcription factor NFκB
CAS Number:
6754-13-8
Purity:
≥96%
Molecular Weight:
262.30
Molecular Formula:
C15H18O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Helenalin is a potent antiinflammatory and antineoplastic agent. Helanalin induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-XL or Bcl-2 are overexpressed. It has also been shown to inhibit NF-kappa B. In vitro studies have reported that Helenalin is capable of alkylating the thiol group of reduced glutathione and L-cysteine. Additionally, it has shown cytotoxic activity against H.EP-2 tumor cells.
Helenalin (CAS 6754-13-8) References
- Validation and subsequent development of the DEREK skin sensitization rulebase by analysis of the BgVV list of contact allergens. | Barratt, MD. and Langowski, JJ. 1999. J Chem Inf Comput Sci. 39: 294-8. PMID: 10192944
- Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells. | Tornhamre, S., et al. 2001. Biochem Pharmacol. 62: 903-11. PMID: 11543725
- Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. | Schmidt, TJ., et al. 2002. Planta Med. 68: 750-1. PMID: 12221603
- Chemical substances and contact allergy--244 substances ranked according to allergenic potency. | Schlede, E., et al. 2003. Toxicology. 193: 219-59. PMID: 14599761
- Potent inhibition of human telomerase by helenalin. | Huang, PR., et al. 2005. Cancer Lett. 227: 169-74. PMID: 16112419
- Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones. | Giordano, OS., et al. 1992. J Med Chem. 35: 2452-8. PMID: 1619619
- Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. | Berges, C., et al. 2009. Mol Immunol. 46: 2892-901. PMID: 19656571
- Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways. | Schröder, H., et al. 1990. Thromb Res. 57: 839-45. PMID: 2116680
- NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. | Lim, CB., et al. 2012. BMC Complement Altern Med. 12: 93. PMID: 22784363
- The structural basis of the mutagenicity of chemicals in Salmonella typhimurium: the Gene-Tox data base. | Klopman, G., et al. 1990. Mutat Res. 228: 1-50. PMID: 2405259
- Helenalin - A Sesquiterpene Lactone with Multidirectional Activity. | Drogosz, J. and Janecka, A. 2019. Curr Drug Targets. 20: 444-452. PMID: 30317996
- IL-17 aggravates renal injury by promoting podocyte injury in children with primary nephrotic syndrome. | Zhai, S., et al. 2020. Exp Ther Med. 20: 409-417. PMID: 32537005
- Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships. | Hayashi, T., et al. 1987. J Med Chem. 30: 2005-8. PMID: 3669007
- Indirect inactivation of rabbit reticulocyte initiation factor eIF-2 by helenalin and bis(helenalinyl) malonate. | Williams, WL., et al. 1984. Biochemistry. 23: 5637-44. PMID: 6095903
- Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB. | Lyss, G., et al. 1997. Biol Chem. 378: 951-61. PMID: 9348104
- The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. | Lyss, G., et al. 1998. J Biol Chem. 273: 33508-16. PMID: 9837931
Inhibitor of:
NF kappa B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Helenalin, 500 µg | sc-218579 | 500 µg | $326.00 |