Molecular structure of 5-Hydroxy Tryptophan, CAS Number: 56-69-9
5-Hydroxy Tryptophan (CAS 56-69-9)
Alternate Names:
5-HTP
Application:
5-Hydroxy Tryptophan is a tryptophan (sc-286892) metabolite
CAS Number:
56-69-9
Molecular Weight:
220.22
Molecular Formula:
C11H12N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-Hydroxy Tryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor that is used to assess central serotonergic function. It is found in a variety of foods and dietary supplements, and is widely used for its purported anxiolytic, antidepressant, and sleep-promoting effects. In addition to its role in the synthesis of serotonin, 5-HTP has been studied for its potential effects in a number of different areas, including obesity, fibromyalgia, and Parkinson′s disease. Furthermore, it can modulate dopamine, norepinephrine, and GABA levels, as well as the stimulate the hypothalamic-pituitary-adrenal (HPA) axis.
5-Hydroxy Tryptophan (CAS 56-69-9) References
- Studies with compounds that compete with tryptophan binding to rat hepatic nuclei. | Sidransky, H., et al. 1992. J Nutr. 122: 1085-95. PMID: 1373445
- Modifications of tryptophan oxidation by phenolic-rich plant materials. | Salminen, H., et al. 2008. J Agric Food Chem. 56: 11178-86. PMID: 19007128
- 5-Hydroxy-tryptophan for the treatment of L-DOPA-induced dyskinesia in the rat Parkinson's disease model. | Tronci, E., et al. 2013. Neurobiol Dis. 60: 108-14. PMID: 24004632
- Hydroxy-tryptophan containing derivatives of tritrpticin: modification of antimicrobial activity and membrane interactions. | Arias, M., et al. 2015. Biochim Biophys Acta. 1848: 277-88. PMID: 25178967
- Sex-linked differences in cortisol, ACTH and prolactin responses to 5-hydroxy-tryptophan in healthy controls and minor and major depressed patients. | Maes, M., et al. 1989. Acta Psychiatr Scand. 80: 584-90. PMID: 2559587
- Altered tryptophan metabolism in human meningioma. | Talari, NK., et al. 2016. J Neurooncol. 130: 69-77. PMID: 27473286
- On the efficient bio-incorporation of 5-hydroxy-tryptophan in recombinant proteins expressed in Escherichia coli with T7 RNA polymerase-based vectors. | Oliveira-Souza, WP., et al. 2017. Biochem Biophys Res Commun. 492: 343-348. PMID: 28859987
- Post-hypoxic intention myoclonus treated with 5-hydroxy-tryptophan and an extracerebral decarboxylase inhibitor. | Magnussen, I., et al. 1978. Acta Neurol Scand. 57: 289-94. PMID: 307327
- Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems. | Raleigh, MJ. 1987. Psychopharmacology (Berl). 93: 44-50. PMID: 3114814
- Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients. | Crotti, S., et al. 2020. Front Oncol. 10: 583228. PMID: 33178611
- Attenuation of Hypothyroidism-Induced Cognitive Impairment by Modulating Serotonin Mediation. | Bakalov, D., et al. 2023. Vet Sci. 10: PMID: 36851426
- Simultaneous determination of 5-hydroxy tryptophan, serotonin and 5-hydroxy indoleacetic acid in the brain by liquid chromatography with electrochemical detection. | Santagostino, G., et al. 1982. Farmaco Prat. 37: 365-70. PMID: 6184244
- Naloxone blocks the effect of 5-hydroxy-tryptophan on passive avoidance learning in rats: implication of endogenous opiod peptides. | Garzón, J., et al. 1981. Life Sci. 29: 17-25. PMID: 6973682
- Changes in the albumin binding of tryptophan during postoperative recovery: a possible link with central fatigue? | Yamamoto, T., et al. 1997. Brain Res Bull. 43: 43-6. PMID: 9205793
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SR-3A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-Hydroxy Tryptophan, 5 g | sc-217201 | 5 g | $437.00 |