Date published: 2025-10-16

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Sodium thioglycolate (CAS 367-51-1)

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Alternate Names:
Sodium mercaptoacetate; Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt
Application:
Sodium thioglycolate is a disulfide reducing agent
CAS Number:
367-51-1
Molecular Weight:
114.10
Molecular Formula:
C2H3O2S•Na
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium thioglycolate is a sulfur-containing organic compound. It is a reducing agent, to break disulfide bonds in proteins. Sodium thioglycolate is to prevent the oxidation of growth factors and other sensitive components. It is utilized in the isolation of intact mitochondria from cells, as it helps to maintain the redox state of the organelles. Sodium thioglycolate is effective in the stabilization of enzymes and other proteins, making it an important reagent in various biochemical assays.


Sodium thioglycolate (CAS 367-51-1) References

  1. The effect of reducing agents on the recovery of injured Bifidobacterium cells.  |  Nebra, Y., et al. 2002. J Microbiol Methods. 49: 247-54. PMID: 11869789
  2. Fluorescence for the determination of protein with functionalized nano-ZnS.  |  Wang, LY., et al. 2002. Analyst. 127: 1531-4. PMID: 12475047
  3. Developmental toxicity evaluation of sodium thioglycolate administered topically to Sprague-Dawley (CD) rats and New Zealand White rabbits.  |  Tyl, RW., et al. 2003. Birth Defects Res B Dev Reprod Toxicol. 68: 144-61. PMID: 12866706
  4. Some aspects of the absorption, distribution and excretion of sodium thioglycolate.  |  DRAIZE, JH., et al. 1956. J Pharmacol Exp Ther. 118: 304-8. PMID: 13377298
  5. Efficacy of some neutralizers in suspension tests determining the activity of disinfectants.  |  Espigares, E., et al. 2003. J Hosp Infect. 55: 137-40. PMID: 14529639
  6. Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation.  |  Golubeva, MG., et al. 2012. Bull Exp Biol Med. 153: 295-7. PMID: 22866294
  7. Synthesis and characterization of antibacterial silver nanoparticle-impregnated rice husks and rice husk ash.  |  He, D., et al. 2013. Environ Sci Technol. 47: 5276-84. PMID: 23614704
  8. Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate.  |  Rhodes, DG., et al. 2015. Vaccine. 33: 6011-6. PMID: 26409814
  9. In vitro cytotoxicity and phototoxicity of surface-modified gold nanoparticles associated with neutral red as a potential drug delivery system in phototherapy.  |  Verissimo, TV., et al. 2016. Mater Sci Eng C Mater Biol Appl. 65: 199-204. PMID: 27157744
  10. Understanding the dynamics of keratin weakening and hydrolysis by proteases.  |  Navone, L. and Speight, R. 2018. PLoS One. 13: e0202608. PMID: 30114294
  11. Comparison of Oxygen Scavengers for Their Ability to Enhance Resuscitation of Heat-injured Listeria monocytogenes.  |  Patel, JR., et al. 1995. J Food Prot. 58: 244-250. PMID: 31137297
  12. Effect of combination of Oxyrase and sodium thioglycolate on growth of Clostridium perfringens from spores under aerobic incubation.  |  Jia, Z., et al. 2020. Food Microbiol. 89: 103413. PMID: 32138984
  13. Toxicity studies of sodium thioglycolate administered dermally to F344/N rats and B6C3F1/N mice.  |  ,. 2016. Toxic Rep Ser.. PMID: 33530656
  14. Chondroitin Sulfate from Oreochromis niloticus Waste Reduces Leukocyte Influx in an Acute Peritonitis Model.  |  Silva, MB., et al. 2023. Molecules. 28: PMID: 37049845
  15. Dissimilatory nitrate reduction to nitrate, nitrous oxide, and ammonium by Pseudomonas putrefaciens.  |  Samuelsson, MO. 1985. Appl Environ Microbiol. 50: 812-5. PMID: 4083881

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium thioglycolate, 25 g

sc-215887
25 g
$37.00

Sodium thioglycolate, 100 g

sc-215887A
100 g
$80.00

Sodium thioglycolate, 250 g

sc-215887B
250 g
$140.00

Sodium thioglycolate, 1 kg

sc-215887C
1 kg
$460.00

Sodium thioglycolate, 5 kg

sc-215887D
5 kg
$1900.00