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p-Coumaric acid (CAS 501-98-4)

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Alternate Names:
trans-4-Hydroxycinnamic acid
Application:
p-Coumaric acid is a hydroxycinnamic acid with antioxidant properties
CAS Number:
501-98-4
Purity:
≥99%
Molecular Weight:
164.16
Molecular Formula:
C9H8O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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p-Coumaric acid, a hydroxycinnamic acid derivative characterized by the presence of a phenolic ring and an unsaturated carboxylic acid group, plays a pivotal role in the plant kingdom and in various research fields due to its significant biological activities. Its mechanism of action is primarily attributed to its antioxidant properties, where it acts as a free radical scavenger, mitigating oxidative stress within cells. This compound is also involved in the biosynthesis of lignin, a critical structural polymer in plant cell walls, enhancing plant rigidity and resistance against pathogens. In research applications, p-Coumaric acid is utilized as a model compound to study phenolic biosynthesis pathways and to understand the ecological interactions between plants and their environment, including stress response mechanisms. Its ability to absorb UV light makes it an interesting candidate for studying natural photoprotection mechanisms in plants. Furthermore, its role as a precursor in the synthesis of other biologically significant compounds, such as flavonoids and stilbenes, underscores its importance in metabolic engineering efforts aimed at producing bioactive compounds with potential applications in agriculture and materials science.


p-Coumaric acid (CAS 501-98-4) References

  1. p-Coumaric acid improves oxidative and osmosis stress responses in Caenorhabditis elegans.  |  Yue, Y., et al. 2019. J Sci Food Agric. 99: 1190-1197. PMID: 30047165
  2. Intensification of p-coumaric acid heterologous production using extractive biphasic fermentation.  |  Combes, J., et al. 2021. Bioresour Technol. 337: 125436. PMID: 34182346
  3. p-Coumaric acid mitigates lipopolysaccharide induced brain damage via alleviating oxidative stress, inflammation and apoptosis.  |  Daroi, PA., et al. 2022. J Pharm Pharmacol. 74: 556-564. PMID: 34190326
  4. p-Coumaric acid attenuates high-fat diet-induced oxidative stress and nephropathy in diabetic rats.  |  Mani, A., et al. 2022. J Anim Physiol Anim Nutr (Berl). 106: 872-880. PMID: 34596925
  5. Protective effects of p-coumaric acid against gentamicin-induced nephrotoxicity in rats.  |  Hakyemez, IN., et al. 2022. Drug Chem Toxicol. 45: 2825-2832. PMID: 34702126
  6. p-Coumaric acid regulates macrophage polarization in myocardial ischemia/reperfusion by promoting the expression of indoleamine 2, 3-dioxygenase.  |  Li, N., et al. 2021. Bioengineered. 12: 10971-10981. PMID: 34738873
  7. P-coumaric acid ameliorates fipronil induced liver injury in mice through attenuation of structural changes, oxidative stress and inflammation.  |  Bal, SS., et al. 2022. Pestic Biochem Physiol. 180: 104997. PMID: 34955181
  8. p-Coumaric acid suppresses reactive oxygen species-induced senescence in nucleus pulposus cells.  |  Sheng, K., et al. 2022. Exp Ther Med. 23: 183. PMID: 35069864
  9. De novo biosynthesis of p-coumaric acid and caffeic acid from carboxymethyl-cellulose by microbial co-culture strategy.  |  Cai, M., et al. 2022. Microb Cell Fact. 21: 81. PMID: 35538542
  10. Identification of p-Coumaric Acid and Ethyl p-Coumarate as the Main Phenolic Components of Hemp (Cannabis sativa L.) Roots.  |  Oh, CM., et al. 2022. Molecules. 27: PMID: 35566134
  11. P-Coumaric Acid Reverses Depression-Like Behavior and Memory Deficit Via Inhibiting AGE-RAGE-Mediated Neuroinflammation.  |  Yu, XD., et al. 2022. Cells. 11: PMID: 35626632
  12. Global transcriptomic response of Escherichia coli to p-coumaric acid.  |  Rodríguez-Ochoa, JI., et al. 2022. Microb Cell Fact. 21: 148. PMID: 35858942
  13. p-Coumaric acid protects against D-galactose induced neurotoxicity by attenuating neuroinflammation and apoptosis in mice brain.  |  Daroi, PA., et al. 2022. Metab Brain Dis. 37: 2569-2579. PMID: 35913570
  14. p-Coumaric acid ameliorates cognitive and non-cognitive disturbances in a rat model of Alzheimer's disease: The role of oxidative stress and inflammation.  |  Ghaderi, S., et al. 2022. Int Immunopharmacol. 112: 109295. PMID: 36194986
  15. Ferulic Acid and P-Coumaric Acid Synergistically Attenuate Non-Alcoholic Fatty Liver Disease through HDAC1/PPARG-Mediated Free Fatty Acid Uptake.  |  Cui, K., et al. 2022. Int J Mol Sci. 23: PMID: 36499624

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

p-Coumaric acid, 1 g

sc-215648
1 g
$27.00

p-Coumaric acid, 5 g

sc-215648A
5 g
$40.00

p-Coumaric acid, 25 g

sc-215648B
25 g
$80.00

p-Coumaric acid, 100 g

sc-215648C
100 g
$290.00

p-Coumaric acid, 500 g

sc-215648D
500 g
$918.00

Hello dear,  I need to purchase a p-coumaric acid, the amount that I need is 50g, but this quantity is not showing in your website. Will you be able please to provide it and what is the price for this amount? 

Asked by: Nouf Alshammari
Thank you for your question. For accurate availability, shipping and pricing information regarding our chemical products, or to receive a quote, please contact Customer Service.
Answered by: Technical Service
Date published: 2023-11-07
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Rated 5 out of 5 by from AdeboyeAdeboye, PT. et al. (PubMed 26392265) found that catabolism of coniferyl aldehyde, ferulic acid and p-Coumaric acid by Saccharomyces cerevisiae yielded less toxic products. -SCBT Publication Review
Date published: 2015-07-05
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p-Coumaric acid is rated 5.0 out of 5 by 1.
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