Molecular structure of Lithocholic acid, CAS Number: 434-13-9
Lithocholic acid (CAS 434-13-9)
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Alternate Names:
3α-Hydroxy-5β-cholan-24-oic acid; 3α-Hydroxy-5β-cholanic acid; 5β-Cholan-24-oic acid-3α-ol; Lithocholate
Application:
Lithocholic acid is a bile acid
CAS Number:
434-13-9
Purity:
≥95%
Molecular Weight:
376.57
Molecular Formula:
C24H40O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Lithocholic acid is frequently utilized in research focusing on bile acid metabolism and its implications for liver function. This compound is a secondary bile acid that is of particular interest due to its involvement in the enterohepatic circulation and its biological effects on the liver and gastrointestinal tract. Researchers use Lithocholic acid to study its cytotoxic effects on hepatocytes and its role in regulating bile acid pools within the body. Additionally, Lithocholic acid is employed in investigations related to its potential signaling functions, including the activation of nuclear receptors and modulation of gene expression involved in lipid metabolism and detoxification pathways.
Lithocholic acid (CAS 434-13-9) References
- Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. | Hofmann, AF. 2004. Drug Metab Rev. 36: 703-22. PMID: 15554243
- Lithocholic acid and derivatives: Antibacterial activity. | do Nascimento, PG., et al. 2015. Steroids. 104: 8-15. PMID: 26216208
- Development of novel lithocholic acid derivatives as vitamin D receptor agonists. | Masuno, H., et al. 2019. Bioorg Med Chem. 27: 3674-3681. PMID: 31300316
- Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating. | Sivcev, S., et al. 2020. J Steroid Biochem Mol Biol. 202: 105725. PMID: 32652201
- Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists. | Sasaki, H., et al. 2021. J Med Chem. 64: 516-526. PMID: 33369416
- Lithocholic acid-based design of noncalcemic vitamin D receptor agonists. | Gaikwad, S., et al. 2021. Bioorg Chem. 111: 104878. PMID: 33853023
- Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians. | Sato, Y., et al. 2021. Nature. 599: 458-464. PMID: 34325466
- Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists. | Yoshihara, A., et al. 2022. Biomolecules. 12: PMID: 35053278
- Synthesis and identification of lithocholic acid 3-sulfate as RORγt ligand to inhibit Th17 cell differentiation. | Xiao, R., et al. 2022. J Leukoc Biol. 112: 835-843. PMID: 35188700
- Synergistic Effect of Lithocholic Acid with Gentamicin against Gram-Positive Bacteria but Not against Gram-Negative Bacteria. | Lv, H., et al. 2022. Molecules. 27: PMID: 35408717
- Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling. | Hu, J., et al. 2022. Int J Biol Sci. 18: 4545-4559. PMID: 35864954
- Lithocholic acid promotes rosacea-like skin inflammation via G protein-coupled bile acid receptor 1. | Xiao, W., et al. 2022. Biochim Biophys Acta Mol Basis Dis. 1868: 166563. PMID: 36174876
- Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism. | Li, W., et al. 2022. Biochem Pharmacol. 205: 115253. PMID: 36176239
- Secondary bile acid lithocholic acid attenuates neurally evoked ion transport in the rat distal colon. | Takahashi, K., et al. 2022. Biomed Res. 43: 223-239. PMID: 36517024
- Lithocholic acid promotes skeletal muscle regeneration through the TGR5 receptor. | Sun, L., et al. 2023. Acta Biochim Biophys Sin (Shanghai). 55: 51-61. PMID: 36647725
Inhibitor of:
CdcA3, CYP7A1, CYP7B1, Gastrokine 2, Sialyltransferase 7B, St3Gal-I, and ST6GAL2.Activator of:
α-defensin, β-defensin 4, 4921521F21Rik, AKR1CL2, AKR1D1, Asbt, BAAT, BSDC1, Calcitriol, colipase, CYP24, CYP26A1, CYP27B1, CYP2R1, CYP4A12B, Cyp4f17, Cyp4f37, CYP8B1, Cytokeratin 75, DAF-12, DR3, Gm694, GPR42, IL-1RAcP, LRIF, LRP5L, LXR alpha, Ly-55A, Mi2-β, MRG1, Mucin 10, Mucin 2, Mucin 3A, netrin-1, NPC1L1, NR5A2, NTCP, OAT, Oatp5, P504S (AMACR), PHYH, Plb1, RAP, REG3α, Retnlb, RORα, RXR beta, SHP, SLC10A6, TGR5, Thomsen-Friedenreich, UGT2B5, and VDR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lithocholic acid, 10 g | sc-215262 | 10 g | $100.00 | |||
Lithocholic acid, 25 g | sc-215262A | 25 g | $272.00 |