Molecular structure of Dichloroacetic acid, CAS Number: 79-43-6
Dichloroacetic acid (CAS 79-43-6)
See product citations (5)
Alternate Names:
Acetic acid; Urner′s liquid
Application:
Dichloroacetic acid is a mitochondrial PDK (pyruvate dehydrogenase kinase) inhibitor
CAS Number:
79-43-6
Purity:
≥98%
Molecular Weight:
128.94
Molecular Formula:
C2H2Cl2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dichloroacetic acid is a simple halogenated acetic acid compound with two chlorides at the alpha-position. Dichloroacetic acid has been demonstrated to inhibit mitochondrial PDK (pyruvate dehydrogenase kinase) and to shift cellular metabolism from glycolysis to glucose oxidation, and these activities have been correlated to interruption of apoptosis resistance in certain cancer cell lines.
Dichloroacetic acid (CAS 79-43-6) References
- A review of analytical methods for the determination of trichloroethylene and its major metabolites chloral hydrate, trichloroacetic acid and dichloroacetic acid. | Delinsky, AD., et al. 2005. Biomed Chromatogr. 19: 617-39. PMID: 15828053
- Dichloroacetic acid degradation employing hydrogen peroxide and UV radiation. | Zalazar, CS., et al. 2007. Chemosphere. 66: 808-15. PMID: 16904730
- A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. | Bonnet, S., et al. 2007. Cancer Cell. 11: 37-51. PMID: 17222789
- Dichloroacetic acid-induced testicular toxicity in male rats and the protective effect of date fruit extract. | El Arem, A., et al. 2017. BMC Pharmacol Toxicol. 18: 17. PMID: 28431577
- Associations of urinary dichloroacetic acid and trichloroacetic acid exposure with platelet indices: Exploring the mediating role of blood pressure in the general population. | Zhang, SH., et al. 2021. J Hazard Mater. 402: 123452. PMID: 32688193
- Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood. | Wang, Y., et al. 2020. Brain Behav. 10: e01801. PMID: 32841551
- Dichloroacetic acid-induced dysfunction in rat hippocampus and the protective effect of curcumin. | Wei, W., et al. 2021. Metab Brain Dis. 36: 545-556. PMID: 33411217
- Protective effects of dichloroacetic acid on endometrial injury and ovarian reserve in an experimental rat model of diabetes mellitus. | Pala, HG., et al. 2021. J Obstet Gynaecol Res. 47: 4319-4328. PMID: 34595798
- Binary Prodrug of Dichloroacetic Acid and Doxorubicin with Enhanced Anticancer Activity. | Sharma, A., et al. 2021. ACS Appl Bio Mater. 4: 2026-2032. PMID: 35014328
- Cytotoxic derivatives of dichloroacetic acid and some metal complexes. | Hossain, M., et al. 2022. Arch Pharm (Weinheim). 355: e2200236. PMID: 35986437
- Combined Treatment of Dichloroacetic Acid and Pyruvate Increased Neuronal Survival after Seizure. | Lee, SH., et al. 2022. Nutrients. 14: PMID: 36432491
- Dichloroacetic acid and rapamycin synergistically inhibit tumor progression. | Chen, H., et al. 2023. J Zhejiang Univ Sci B. 24: 397-405. PMID: 37190889
- Spermatotoxicity of dichloroacetic acid. | Linder, RE., et al. 1997. Reprod Toxicol. 11: 681-8. PMID: 9311576
Inhibitor of:
3 BP-1, AATM, BDH1, CPS1, CYTIP, EG433182, ENO4, Enzyme, FAHD1, G3PP, GK3P, HDMCP, HMGCL, IER2, L2HGDH, LIPT1, MAAI, MAB21L1, ME1, MPC1L, NADK, NDUFB6, NDUFC2, OGG2, PDDC1, PDHA2, PDK, PDPc, PDPR, Per3, PFK-2 tes, PGLS, PPC-DC, PYGM, SDHA, Speedy C, and TKTL1 (transketolase).Activator of:
α3d Tubulin, γ Enolase, ANT2, ATPAF2, brain and placenta PFK-2, C030010C08Rik, citrate synthase, COX5a, D(−)-Lactate Dehydrogenase, D10Jhu81e, DNC, E3BP, EG433182, EG546368, EG623286, GTPBP3, HCCR-1, L-Lactate Dehydrogenase, LDH-A, LETM1, LIPT1, LOC100041106, LOC730098, MCM3, MCT9, Mitofilin, NAPRT, p14 ARF/p16, p32, p60 Mitochondrial Marker, PDH-E1β, PDK1, PDK4, PGK1, PRPF38B, SDHAF2, SDHC, Spi13, SUCLA2, Tim10, Tim8B, UCP2, ZADH2, and ZBTB43.Substrate of:
GSTT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dichloroacetic acid, 25 g | sc-214877 | 25 g | $60.00 | |||
Dichloroacetic acid, 100 g | sc-214877A | 100 g | $125.00 |