Boldine (CAS 476-70-0)
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Boldine, an aporphine alkaloid originally obtained from the leaves of Peumus boldus, exhibits potent antioxidant properties and serves as a remarkable free-radical scavenger. Notably, it has demonstrated robust cytoprotective abilities in vitro, safeguarding red blood cells against chemically induced hemolytic damage. Moreover, research suggests that Boldine may possess anti-inflammatory and antiproliferative characteristics, along with the capacity to induce cell cycle arrest at the G2/M phase. Although the precise mechanism of action of Boldine remains incompletely understood, it is believed to modulate the activity of enzymes involved in inflammation, cell proliferation, and apoptosis. Furthermore, its antioxidative properties contribute to scavenging free radicals and shielding cells from oxidative damage.
Boldine (CAS 476-70-0) References
- Protective effects of boldine against free radical-induced erythrocyte lysis. | Jiménez, I., et al. 2000. Phytother Res. 14: 339-43. PMID: 10925398
- Boldine and its antioxidant or health-promoting properties. | O'Brien, P., et al. 2006. Chem Biol Interact. 159: 1-17. PMID: 16221469
- Antioxidant and pro-oxidant properties of boldine on hippocampal slices exposed to oxygen-glucose deprivation in vitro. | Konrath, EL., et al. 2008. Neurotoxicology. 29: 1136-40. PMID: 18590764
- Boldine: a potential new antiproliferative drug against glioma cell lines. | Gerhardt, D., et al. 2009. Invest New Drugs. 27: 517-25. PMID: 19050827
- Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes. | Lau, YS., et al. 2015. J Cardiovasc Pharmacol. 65: 522-31. PMID: 25469805
- Boldine, a natural aporphine alkaloid, inhibits telomerase at non-toxic concentrations. | Kazemi Noureini, S. and Tanavar, F. 2015. Chem Biol Interact. 231: 27-34. PMID: 25746354
- Sub-chronic boldine treatment exerts anticonvulsant effects in mice. | Moezi, L., et al. 2018. Neurol Res. 40: 146-152. PMID: 29157166
- Acute Boldine Treatment Induces Anti-convulsant Effects in Mice through its Antioxidant Activity. | Moezi, L., et al. 2019. Drug Res (Stuttg). 69: 227-233. PMID: 30081409
- Boldine Ameliorates Estrogen Deficiency-Induced Bone Loss via Inhibiting Bone Resorption. | Chen, K., et al. 2018. Front Pharmacol. 9: 1046. PMID: 30271347
- Hepatoprotective effect of boldine against diethylnitrosamine-induced hepatocarcinogenesis in wistar rats. | Subramaniam, N., et al. 2019. J Biochem Mol Toxicol. 33: e22404. PMID: 31593341
- Boldine inhibits the alveolar bone resorption during ligature-induced periodontitis by modulating the Th17/Treg imbalance. | Cafferata, EA., et al. 2021. J Periodontol. 92: 123-136. PMID: 32490537
- Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer's Disease. | Toledo, JP., et al. 2021. Front Neurosci. 15: 617821. PMID: 33679301
- Boldine, an Alkaloid from Peumus boldus Molina, Induces Endothelium-Dependent Vasodilation in the Perfused Rat Kidney: Involvement of Nitric Oxide and Small-Conductance Ca2+-Activated K+ Channel. | de Souza, P., et al. 2022. Evid Based Complement Alternat Med. 2022: 4560607. PMID: 35222671
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Boldine, 1 g | sc-214617 | 1 g | $40.00 | |||
Boldine, 5 g | sc-214617A | 5 g | $140.00 |