Molecular structure of Thiocholesterol, CAS Number: 1249-81-6
Thiocholesterol (CAS 1249-81-6)
Alternate Names:
5-Cholestene-3β-thiol; Cholesteryl mercaptan
Application:
Thiocholesterol is a compound used in biological cross-linking and membrane studies
CAS Number:
1249-81-6
Molecular Weight:
402.72
Molecular Formula:
C27H46S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thiocholesterol is a compound used in biological cross-linking and membrane studies. It is a key component of many biological processes, including the synthesis of hormones, cholesterol transport, and the regulation of gene expression. It is known that thiocholesterol binds to membrane-bound proteins, such as G-proteins, and modulates their activity. Additionally, it may act to interact with cholesterol-binding proteins, such as low-density lipoprotein receptors, and has been implicated in the regulation of cholesterol metabolism.
Thiocholesterol (CAS 1249-81-6) References
- Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol. | Zitzer, A., et al. 2003. FEBS Lett. 553: 229-31. PMID: 14572629
- New approach to writing and simultaneous reading of micropatterns: combining surface plasmon resonance imaging with scanning electrochemical microscopy (SECM). | Szunerits, S., et al. 2004. Langmuir. 20: 9236-41. PMID: 15461512
- Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. | Huang, Z., et al. 2005. Mol Ther. 11: 409-17. PMID: 15727937
- Temperature-sensitive poly(N-(2-hydroxypropyl)methacrylamide mono/dilactate)-coated liposomes for triggered contents release. | Paasonen, L., et al. 2007. Bioconjug Chem. 18: 2131-6. PMID: 17963354
- Cholesterol modification of (Bio)polymers using UV-Vis traceable chemistry in aqueous solutions. | Rasmussen, KF., et al. 2014. Macromol Biosci. 14: 33-44. PMID: 24106046
- A calorimetric and spectroscopic comparison of the effects of cholesterol and its sulfur-containing analogs thiocholesterol and cholesterol sulfate on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. | Benesch, MG., et al. 2016. Biochim Biophys Acta. 1858: 168-80. PMID: 26585353
- Regulation of Cholesterol Sulfotransferase SULT2B1b by Hepatocyte Nuclear Factor 4α Constitutes a Negative Feedback Control of Hepatic Gluconeogenesis. | Bi, Y., et al. 2018. Mol Cell Biol. 38: PMID: 29378829
- Substrate-led cholesterol extraction from supported lipid membranes. | Miller, EJ., et al. 2018. Nanoscale. 10: 16332-16342. PMID: 30132496
- Studies on phosphatidylcholine vesicles with thiocholesterol and a thiocholesterol-linked spin label incorporated in the vesicle wall. | Huang, C., et al. 1970. Biochemistry. 9: 3422-6. PMID: 4330857
- L-Proline transport in Saccharomyces cerevisiae. | Horák, J. and Ríhová, L. 1982. Biochim Biophys Acta. 691: 144-50. PMID: 6753931
- Interaction of cholesterol and cholesterol analogs with egg phosphatidylcholine in a lipid solvent. | Oppenheimer, NJ. and Cordes, EH. 1981. J Biol Chem. 256: 6714-20. PMID: 7195401
- The rapid transbilayer movement of thiocholesterol in small unilamellar phospholipid vesicles. | Dawidowicz, EA. and Backer, JM. 1981. Biochim Biophys Acta. 644: 373-5. PMID: 7260079
- Mercapto steroids in protection against mercury and lead poisoning. | Blickenstaff, RT., et al. 1980. J Pharm Sci. 69: 556-8. PMID: 7381742
- Human plasma lecithin:cholesterol acyltransferase. On the substrate efficiency of cholest-5-ene-3 beta-thiol as a fatty acyl acceptor. | Zhou, G. and Dolphin, PJ. 1995. Biochim Biophys Acta. 1258: 101-6. PMID: 7548172
- Antioxidant activity of thiocholesterol on copper-induced oxidation of low-density lipoprotein. | Tanaka, M. and Nakagawa, M. 1995. Lipids. 30: 321-5. PMID: 7609599
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thiocholesterol, 1 g | sc-213033 | 1 g | $582.00 |