Molecular structure of Monocrotaline, CAS Number: 315-22-0
Monocrotaline (CAS 315-22-0)
Alternate Names:
Crotaline
Application:
Monocrotaline is a toxic, pyrrolizidine alkaloid
CAS Number:
315-22-0
Purity:
≥98%
Molecular Weight:
325.36
Molecular Formula:
C16H23NO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Monocrotaline is a toxic, pyrrolizidine alkaloid. It is used for inducing pulmonary diseases in rats. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Monocrotaline is believed to act as an agonist at certain receptors, including the serotonin 5-HT2A receptor, and to interact with various enzymes, including cytochrome P450 enzymes.
Monocrotaline (CAS 315-22-0) References
- Antineoplastic activity of monocrotaline against hepatocellular carcinoma. | Kusuma, SS., et al. 2014. Anticancer Agents Med Chem. 14: 1237-48. PMID: 25028149
- Monocrotaline Induces Endothelial Injury and Pulmonary Hypertension by Targeting the Extracellular Calcium-Sensing Receptor. | Xiao, R., et al. 2017. J Am Heart Assoc. 6: PMID: 28330842
- Monocrotaline Suppresses RANKL-Induced Osteoclastogenesis In Vitro and Prevents LPS-Induced Bone Loss In Vivo. | Wei, CM., et al. 2018. Cell Physiol Biochem. 48: 644-656. PMID: 30025412
- Monocrotaline pyrrole induces pulmonary endothelial damage through binding to and release from erythrocytes in lung during venous blood reoxygenation. | Xiao, R., et al. 2019. Am J Physiol Lung Cell Mol Physiol. 316: L798-L809. PMID: 30785344
- RNA sequencing analysis of monocrotaline-induced PAH reveals dysregulated chemokine and neuroactive ligand receptor pathways. | Xiao, G., et al. 2020. Aging (Albany NY). 12: 4953-4969. PMID: 32176619
- Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach. | Suparmi, S., et al. 2020. Arch Toxicol. 94: 3281-3295. PMID: 32518961
- Serum and pulmonary uric acid in pulmonary arterial hypertension. | Savale, L., et al. 2021. Eur Respir J. 58: PMID: 33446602
- Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study. | Lin, F., et al. 2021. Biomed Chromatogr. 35: e5207. PMID: 34184288
- Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats. | Kawade, A., et al. 2021. J Pharmacol Sci. 147: 81-85. PMID: 34294376
- Recovery of Liver Sinusoidal Endothelial Cells Following Monocrotaline-induced Liver Injury. | Otaka, F., et al. 2021. In Vivo. 35: 2577-2587. PMID: 34410945
- Tetramethylpyrazine Improves Monocrotaline-Induced Pulmonary Hypertension through the ROS/iNOS/PKG-1 Axis. | Yang, DP., et al. 2022. J Healthc Eng. 2022: 1890892. PMID: 35368928
- Preparation of molecularly imprinted foam for selective extraction of toxic monocrotaline from herbs. | He, N., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1200: 123273. PMID: 35537311
- Monocrotaline Toxicity Alters the Function of Hepatocyte Membrane Transporters in Rats. | Pastor, CM. and Vilgrain, V. 2022. Int J Mol Sci. 23: PMID: 35887275
- Activation of Autophagy Induces Monocrotaline-Induced Pulmonary Arterial Hypertension by FOXM1-Mediated FAK Phosphorylation. | Zhai, C., et al. 2022. Lung. 200: 619-631. PMID: 36107242
- Defibrotide improved the outcome of monocrotaline induced rat hepatic sinusoidal obstruction syndrome. | Liu, Z., et al. 2022. BMC Gastroenterol. 22: 525. PMID: 36526956
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Monocrotaline, 10 mg | sc-211921 | 10 mg | $198.00 |