Isopimpinellin (CAS 482-27-9)
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Isopimpinellin functions as a photoactive substance in development applications. It interacts with DNA and forms covalent bonds upon exposure to ultraviolet A (UVA) radiation, leading to the formation of DNA adducts. This process can potentially induce DNA damage and interfere with DNA replication and transcription. Isopimpinellin′s mechanism of action involves the formation of crosslinks with DNA bases, particularly thymine, which can disrupt the normal functioning of the genetic material. Isopimpinellin′s ability to induce DNA damage under specific conditions may be a subject of interest in studies related to photobiology and DNA repair mechanisms. Its role in experimental applications involves investigating the molecular consequences of DNA adduct formation and its potential implications for cellular function.
Isopimpinellin (CAS 482-27-9) References
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- LC determination of impurities in methoxsalen drug substance: isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR. | Lehr, GJ., et al. 2003. J Pharm Biomed Anal. 33: 627-37. PMID: 14623588
- Microbial transformation of Isopimpinellin by Glomerella cingulata. | Marumoto, S. and Miyazawa, M. 2011. J Oleo Sci. 60: 575-8. PMID: 22027023
- Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. | Liu, Z., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 891-892: 102-8. PMID: 22418072
- Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. | Li, J., et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 970: 77-85. PMID: 25240925
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- Isopimpinellin extends antiangiogenic effect through overexpression of miR-15b-5p and downregulating angiogenic stimulators. | Bhagavatheeswaran, S., et al. 2022. Mol Biol Rep. 49: 279-291. PMID: 34709570
- Isopimpinellin is not phototoxic to viruses and cells. | Hudson, JB., et al. 1987. Planta Med. 53: 306-7. PMID: 3628561
- Identification of psoralen, 8-methoxypsoralen, isopimpinellin, and 5,7-dimethoxycoumarin in Pelea anisata H. Mann. | Yoke Marchant, Y., et al. 1985. Contact Dermatitis. 12: 196-9. PMID: 4017567
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isopimpinellin, 10 mg | sc-211673 | 10 mg | $200.00 |