Date published: 2025-10-20

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Isobutyl Paraben (CAS 4247-02-3)

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Alternate Names:
Isobutyl 4-hydroxybenzoate
Application:
Isobutyl Paraben is an anti-microbial agent
CAS Number:
4247-02-3
Molecular Weight:
194.23
Molecular Formula:
C11H14O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Isobutyl Paraben is an anti-microbial agent and anti-fungal agent. Parabens are effective preservatives in many types of formulas. Isobutyl 4-hydroxybenzoate, also known as 4-hydroxybenzoic acid isobutyl ester, is a synthetic compound extensively utilized in laboratory experiments and research. It presents as a white crystalline solid, soluble in organic solvents, and serves as a preservative in food. Its applications span across organic chemistry, biochemistry, and various scientific research domains. Isobutyl 4-hydroxybenzoate finds widespread use as a preservative in food. It contributes to the synthesis of diverse organic compounds like dyes. Additionally, it aids in the production of polymers such as polyurethanes and biodegradable plastics. This compound acts as a weak acid, exerting its mechanism of action through the inhibition of carbohydrate and lipid-metabolizing enzymes. Moreover, it disrupts the cell membranes of bacteria and fungi, believed to hinder their growth.


Isobutyl Paraben (CAS 4247-02-3) References

  1. Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens.  |  Koda, T., et al. 2005. Environ Res. 98: 40-5. PMID: 15721882
  2. Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats.  |  Kawaguchi, M., et al. 2009. Neurosci Res. 65: 136-40. PMID: 19560493
  3. Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats.  |  Kawaguchi, M., et al. 2009. J Vet Med Sci. 71: 1027-33. PMID: 19721353
  4. Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats.  |  Kawaguchi, M., et al. 2010. Exp Anim. 59: 631-5. PMID: 21030791
  5. Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells.  |  Yang, H., et al. 2012. Hum Exp Toxicol. 31: 134-44. PMID: 22027501
  6. Synergistic effects of octylphenol and isobutyl paraben on the expression of calbindin-D₉k in GH3 rat pituitary cells.  |  Kim, YR., et al. 2012. Int J Mol Med. 29: 294-302. PMID: 22076563
  7. Simultaneous determination of nine preservatives in food by liquid chromatography with the aid of coagulant in the clean-up process.  |  Sugiura, J. and Nakajima, M. 2017. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 34: 695-704. PMID: 28277177
  8. In vitro genotoxic and cytotoxic effects of some paraben esters on human peripheral lymphocytes.  |  Güzel Bayülken, D. and Ayaz Tüylü, B. 2019. Drug Chem Toxicol. 42: 386-393. PMID: 29681198
  9. Exploiting green sorbents in rotating-disk sorptive extraction for the determination of parabens by high-performance liquid chromatography with tandem electrospray ionization triple quadrupole mass spectrometry.  |  Vieira, CMS., et al. 2018. J Sep Sci. 41: 4047-4054. PMID: 30168667
  10. Assessment of hepatotoxicity and dermal toxicity of butyl paraben and methyl paraben using HepG2 and HDFn in vitro models.  |  Kizhedath, A., et al. 2019. Toxicol In Vitro. 55: 108-115. PMID: 30572011
  11. An improved fabric-phase sorptive extraction protocol for the determination of seven parabens in human urine by HPLC-DAD.  |  Rigkos, G., et al. 2021. Biomed Chromatogr. 35: e4974. PMID: 32893361
  12. Evaluation of the Effect of Isobutyl Paraben and 2-ethyl Hexyl Paraben on P-glycoprotein Functional Expression in Rats: A Pharmacokinetic Study.  |  Alshogran, OY., et al. 2022. Curr Mol Pharmacol. 15: 987-995. PMID: 35086468
  13. A rapid and environmentally friendly method for determination of parabens preservatives in flavors by supercritical fluid chromatography-tandem mass spectrometry.  |  Yang, F., et al. 2022. J Sep Sci. 45: 3043-3053. PMID: 35621260

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Isobutyl Paraben, 1 g

sc-211665
1 g
$326.00