Date published: 2025-11-20

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Dihydrodaidzein (CAS 17238-05-0)

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Alternate Names:
4′,7-Dihydroxyisoflavanone
Application:
Dihydrodaidzein is a metabolite of Daidzein
CAS Number:
17238-05-0
Purity:
≥97%
Molecular Weight:
256.25
Molecular Formula:
C15H12O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dihydrodaidzein (DHD) is a naturally occurring phytochemical identified in soybeans and other legumes. As a member of the isoflavone family, it contributes significantly to human dietary intake. The precise mechanism of action for Dihydrodaidzein is not completely clear, but it′s hypothesized that it may work as an antioxidant by neutralizing free radicals and alleviating oxidative stress.


Dihydrodaidzein (CAS 17238-05-0) References

  1. Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein, 6'-OH-O-dma, and cis-4-OH-equol in human urine by gas chromatography-mass spectroscopy using authentic reference compounds.  |  Heinonen, S., et al. 1999. Anal Biochem. 274: 211-9. PMID: 10527518
  2. Comparative metabolism of genistin by human and rat gut microflora: detection and identification of the end-products of metabolism.  |  Coldham, NG., et al. 2002. Xenobiotica. 32: 45-62. PMID: 11820509
  3. Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS.  |  Fang, N., et al. 2002. J Agric Food Chem. 50: 2700-7. PMID: 11958644
  4. Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats.  |  Bowey, E., et al. 2003. Food Chem Toxicol. 41: 631-6. PMID: 12659715
  5. Enhanced biosynthesis of dihydrodaidzein and dihydrogenistein by a newly isolated bovine rumen anaerobic bacterium.  |  Wang, XL., et al. 2005. J Biotechnol. 115: 261-9. PMID: 15639088
  6. Enantioselective synthesis of S-equol from dihydrodaidzein by a newly isolated anaerobic human intestinal bacterium.  |  Wang, XL., et al. 2005. Appl Environ Microbiol. 71: 214-9. PMID: 15640190
  7. Production of dihydrodaidzein and dihydrogenistein by a novel oxygen-tolerant bovine rumen bacterium in the presence of atmospheric oxygen.  |  Zhao, H., et al. 2011. Appl Microbiol Biotechnol. 92: 803-13. PMID: 21626023
  8. Identification and expression of genes involved in the conversion of daidzein and genistein by the equol-forming bacterium Slackia isoflavoniconvertens.  |  Schröder, C., et al. 2013. Appl Environ Microbiol. 79: 3494-502. PMID: 23542626
  9. Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes.  |  Kobayashi, S., et al. 2013. Biosci Biotechnol Biochem. 77: 2210-7. PMID: 24200780
  10. Relative Inhibitions of 5-Lipoxygenase and Myeloperoxidase and Free-Radical Scavenging Activities of Daidzein, Dihydrodaidzein, and Equol.  |  Tsen, SY., et al. 2016. J Med Food. 19: 543-8. PMID: 27027338
  11. Dihydrodaidzein and 6-hydroxydaidzein mediate the fermentation-induced increase of antiosteoporotic effect of soybeans in ovariectomized mice.  |  Kim, JS., et al. 2019. FASEB J. 33: 3252-3263. PMID: 30376359
  12. Application of recombinant lactic acid bacteria and bifidobacteria able to enrich soy beverage in dihydrodaidzein and dihydrogenistein.  |  Peirotén, Á., et al. 2020. Food Res Int. 134: 109257. PMID: 32517924
  13. The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin.  |  Kato, M., et al. 2021. Front Pharmacol. 12: 628968. PMID: 33897420
  14. Heterologous expression of equol biosynthesis genes from Adlercreutzia equolifaciens.  |  Vázquez, L., et al. 2021. FEMS Microbiol Lett. 368: PMID: 34173644
  15. Metabolism of daidzein and genistein by intestinal bacteria.  |  Chang, YC. and Nair, MG. 1995. J Nat Prod. 58: 1892-6. PMID: 8691209

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dihydrodaidzein, 10 mg

sc-207580A
10 mg
$290.00

Dihydrodaidzein, 25 mg

sc-207580B
25 mg
$320.00

Dihydrodaidzein, 50 mg

sc-207580
50 mg
$420.00

Dihydrodaidzein, 100 mg

sc-207580C
100 mg
$800.00

Dihydrodaidzein, 250 mg

sc-207580D
250 mg
$1600.00

Dihydrodaidzein, 500 mg

sc-207580E
500 mg
$3000.00