Molecular structure of 2-Aminoisobutyric acid, CAS Number: 62-57-7
2-Aminoisobutyric acid (CAS 62-57-7)
Alternate Names:
α-Aminoisobutyric acid
Application:
2-Aminoisobutyric acid is a functional component in the alanine cycle
CAS Number:
62-57-7
Purity:
≥99%
Molecular Weight:
103.12
Molecular Formula:
C4H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Aminoisobutyric acid (2-AIB), also known as 2-methylalanine (2-MeA), is an indispensable amino acid that serves as a intermediate in the synthesis.The multifaceted properties of 2-Aminoisobutyric acid contribute significantly to numerous biochemical and physiological processes. This amino acid finds extensive applications in scientific research, both in vivo and in vitro studies.The amino acid acts as a substrate for transaminases and as a co-substrate for decarboxylases, both of which play pivotal roles in the production of other amino acids.
2-Aminoisobutyric acid (CAS 62-57-7) References
- Solid-state conformation of a hybrid tripeptide between beta-amino acid; 8-aminocyclooct-4-enecarboxylic acid and 2-aminoisobutyric acid. | Tanaka, M., et al. 2001. Chem Pharm Bull (Tokyo). 49: 1178-81. PMID: 11558607
- Characterization of sodium-dependent amino acid transport activity during liver regeneration. | Fowler, FC., et al. 1992. Hepatology. 16: 1187-94. PMID: 1427657
- Stimulus-secretion coupling of arginine-induced insulin release. Effect of 2-aminoisobutyric acid upon ornithine decarboxylase activity and insulin secretion. | Sener, A., et al. 1989. Res Commun Chem Pathol Pharmacol. 65: 65-80. PMID: 2506616
- Chemoenzymatic synthesis of polypeptides containing the unnatural amino acid 2-aminoisobutyric acid. | Tsuchiya, K. and Numata, K. 2017. Chem Commun (Camb). 53: 7318-7321. PMID: 28485427
- Quantification of 2-aminoisobutyric acid impurity in enzalutamide bulk drug substance using hydrophilic interaction chromatography with fluorescence detection. | Douša, M. 2019. J Pharm Biomed Anal. 164: 296-301. PMID: 30412802
- Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery. | Misawa, T., et al. 2019. Chem Commun (Camb). 55: 7792-7795. PMID: 31210205
- In vitro glucose and 2-aminoisobutyric acid uptake by rat interscapular brown adipose tissue. | Zamora, F., et al. 1988. Biochim Biophys Acta. 968: 346-52. PMID: 3278746
- Automated solid-phase concatenation of Aib residues to form long, water-soluble, helical peptides. | Zieleniewski, F., et al. 2020. Chem Commun (Camb). 56: 12049-12052. PMID: 32902536
- Changes in 2-aminoisobutyric acid and cycloleucine uptake produced by 2,4-dichlorophenoxyacetic acid in Chinese hamster ovary cells. | Bergesse, JR., et al. 1987. Toxicol Lett. 36: 189-96. PMID: 3576650
- The accumulation of 2-aminoisobutyric acid in the costal and lumbar parts of the phrenectomized rat diaphragm in vitro. | Mamatas, SC. and Oja, SS. 1987. Acta Physiol Scand. 130: 201-7. PMID: 3604710
- Transport of 2-aminoisobutyric acid in cultured endothelial cells. | Lau, YT., et al. 1994. Biochim Biophys Acta. 1194: 118-22. PMID: 8075124
- The effect of retinoic acid on amino acid uptake and protein synthesis by lung fibroblasts. | Krupsky, M., et al. 1993. J Biol Chem. 268: 23283-8. PMID: 8226851
- Phenobarbital transiently stimulates uptake of 2-aminoisobutyric acid in hepatocytes. | Leibold, E. and Schwarz, LR. 1996. Arch Toxicol. 70: 368-72. PMID: 8975636
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SNAT5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Aminoisobutyric acid, 25 g | sc-206398 | 25 g | $50.00 | |||
2-Aminoisobutyric acid, 100 g | sc-206398A | 100 g | $129.00 |