Date published: 2025-12-18

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D-(+)-Malic acid (CAS 636-61-3)

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CAS Number:
636-61-3
Molecular Weight:
134.087
Molecular Formula:
C4H6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D-(+)-Malic acid is an inhibitor that binds to dinucleotide phosphate and inhibits enzyme activities. Its application in analytical methods involves determining the concentration of malonic acid and related compounds by assessing the changes in chemical stability of the inhibitor. With its chiral nature and stability, D-(+)-Malic acid is useful for studies of microbial metabolism. Additionally, its high kinetic constant makes it particularly useful for investigating cell lysis in E. coli K-12. D-(+)-Malic acid is a selective α-amino protecting reagent for amino acid derivatives. Moreover, it serves as a versatile synthon in the synthesis of chiral compounds, including -opioid receptor agonists, 1a,25-dihydroxyvitamin D3 analogues, and phoslactomycin B.


D-(+)-Malic acid (CAS 636-61-3) References

  1. High Content of Hydroxycinnamic Acids Esterified with (+)-D-Malic Acid in the Upper Parts of Fumaria officinalis1.  |  Hahn, R. and Nahrstedt, A. 1993. Planta Med. 59: 189-90. PMID: 17230358
  2. Absolute configuration determination of pharmaceutical crystalline powders by MicroED via chiral salt formation.  |  Wang, B., et al. 2022. Chem Commun (Camb). 58: 4711-4714. PMID: 35293405
  3. Metabonomics study of liver and kidney subacute toxicity induced by garidi-5 in rats.  |  Wurihan, ., et al. 2022. Chin Herb Med. 14: 422-431. PMID: 36118012
  4. Alpiniae oxyphylla fructus extract promotes longevity and stress resistance of C. elegans via DAF-16 and SKN-1.  |  Xiao, M., et al. 2022. Front Pharmacol. 13: 1034515. PMID: 36506568
  5. Ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry based untargeted metabolomics to reveal the characteristics of Dictyophora rubrovolvata from different drying methods.  |  Dong, H., et al. 2022. Front Nutr. 9: 1056598. PMID: 36519000
  6. Magnesium Nutrient Application Induces Metabolomics and Physiological Responses in Mulberry (Morus alba) Plants.  |  Jin, X., et al. 2023. Int J Mol Sci. 24: PMID: 37298601
  7. Effects of Ganoderma lucidum polysaccharide peptide ameliorating cyclophosphamide-induced immune dysfunctions based on metabolomics analysis.  |  Xie, J., et al. 2023. Front Nutr. 10: 1179749. PMID: 37305093

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D-(+)-Malic acid, 1 g

sc-206066
1 g
$71.00