Vidarabine (CAS 5536-17-4)
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Vidarabine is a nucleoside analog extensively studied in the field of virology for its mechanism of action in cellular models. Researchers are particularly interested in its ability to interfere with viral DNA polymerase, which provides insights into the replication strategies of DNA viruses. In biochemical research, vidarabine serves as a tool to understand the subtleties of nucleic acid synthesis and the potential for analog incorporation, which has broader implications for understanding genetic replication and transcription fidelity. It also plays a role in investigating enzyme inhibition, offering a model to study the dynamics of molecular interactions between nucleoside analogs and enzymes. Additionally, the compound is used to examine the structural basis for the selectivity and potency of nucleoside analogs against viral targets, contributing to the broader field of antiviral research.
Vidarabine (CAS 5536-17-4) References
- Antiherpetic activities of acidic protein bound polysacchride isolated from Ganoderma lucidum alone and in combinations with acyclovir and vidarabine. | Oh, KW., et al. 2000. J Ethnopharmacol. 72: 221-7. PMID: 10967475
- Vidarabine and 2-deoxycoformycin as antileukemic agents against monocytic leukemia. | Honma, Y. and Niitsu, N. 2000. Leuk Lymphoma. 39: 57-66. PMID: 10975384
- Therapeutic trials for a rabbit model of EBV-associated Hemophagocytic Syndrome (HPS): effects of vidarabine or CHOP, and development of Herpesvirus papio (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease. | Hayashi, K., et al. 2003. Histol Histopathol. 18: 1155-68. PMID: 12973684
- Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. | Kurosaki, K., et al. 2004. Antivir Chem Chemother. 15: 281-5. PMID: 15535050
- Adenosine receptors as therapeutic targets. | Jacobson, KA. and Gao, ZG. 2006. Nat Rev Drug Discov. 5: 247-64. PMID: 16518376
- Effect of a novel adenosine deaminase inhibitor (co-vidarabine, co-V) upon the antiviral activity in vitro and in vivo of vidarabine (Vira-Atm) for DNA virus replication. | Sloan, BJ., et al. 1977. Ann N Y Acad Sci. 284: 60-80. PMID: 212990
- Vidarabine is neither a potent nor a selective AC5 inhibitor. | Seifert, R. 2014. Biochem Pharmacol. 87: 543-6. PMID: 24398424
- Inhibition of adenosine deaminase by co-vidarabine and its effect on the metabolic disposition of adenine arabinoside (vidarabine). | Borondy, PE., et al. 1977. Ann N Y Acad Sci. 284: 9-20. PMID: 280160
- Synthesis and antiviral effect of phosphamide modified vidarabine for treating HSV 1 infections. | Wang, Z., et al. 2021. Bioorg Med Chem Lett. 52: 128405. PMID: 34624489
- Effect of combined acyclovir and vidarabine on infection with herpes simplex virus in vitro and in vivo. | Park, NH., et al. 1984. J Infect Dis. 149: 757-62. PMID: 6327850
- Vidarabine encephalopathy. | Cullis, PA. and Cushing, R. 1984. J Neurol Neurosurg Psychiatry. 47: 1351-4. PMID: 6512557
- Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice. | Shannon, WM., et al. 1983. Antimicrob Agents Chemother. 24: 538-43. PMID: 6651280
- Formulation of a stable vidarabine infusion fluid. | Stolk, LM., et al. 1983. Pharm Weekbl Sci. 5: 57-60. PMID: 6866715
- Toxicity of vidarabine. | Sacks, SL., et al. 1979. JAMA. 241: 28-9. PMID: 758490
- Effect of vidarabine and related compounds on corneal endothelium. | Hull, DS., et al. 1977. Invest Ophthalmol Vis Sci. 16: 545-9. PMID: 863615
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vidarabine, 100 mg | sc-205881 | 100 mg | $52.00 | |||
Vidarabine, 500 mg | sc-205881A | 500 mg | $137.00 |