Molecular structure of Tanshinone I, CAS Number: 568-73-0
Tanshinone I (CAS 568-73-0)
Alternate Names:
Tanshinon I, Tanshinone A, Tanshinquinone I
Application:
Tanshinone I is a biochemical that displays cytotoxicity against IFN-g production in KLH-primed lymph node cells
CAS Number:
568-73-0
Molecular Weight:
276.29
Molecular Formula:
C18H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tanshinone I is a pigment isolated from the herbal medicine Salvia miltiorrhiza Bunge. Tanshinone I displays cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells. Tanshinone I is a diterpenoid compound. It has demonstrated anti-inflammatory, anti-oxidative, and anti-apoptotic properties.
Tanshinone I (CAS 568-73-0) References
- Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers. | Jing, X., et al. 2016. Cancer Chemother Pharmacol. 77: 1171-81. PMID: 27100736
- Tanshinone I attenuates proliferation and chemoresistance of cervical cancer in a KRAS-dependent manner. | Dun, S. and Gao, L. 2019. J Biochem Mol Toxicol. 33: e22267. PMID: 30506648
- Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/phosphatidylinositol-3-kinase signaling pathway. | Wu, YT., et al. 2019. Eur J Pharmacol. 853: 93-102. PMID: 30878387
- Tanshinone I inhibits the growth and metastasis of osteosarcoma via suppressing JAK/STAT3 signalling pathway. | Wang, W., et al. 2019. J Cell Mol Med. 23: 6454-6465. PMID: 31293090
- Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis. | Wang, X., et al. 2019. Drug Des Devel Ther. 13: 3559-3568. PMID: 31686786
- Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K/AKT/mTOR pathway. | Zhou, J., et al. 2020. Cell Prolif. 53: e12739. PMID: 31820522
- Tanshinone I regulates autophagic signaling via the activation of AMP-activated protein kinase in cancer cells. | Zheng, L., et al. 2020. Anticancer Drugs. 31: 601-608. PMID: 32011366
- Tanshinone I induces apoptosis and protective autophagy in human glioblastoma cells via a reactive oxygen species‑dependent pathway. | Jian, S., et al. 2020. Int J Mol Med. 45: 983-992. PMID: 32124953
- Tanshinone I inhibited growth of human chronic myeloid leukemia cells via JNK/ERK mediated apoptotic pathways. | Sun, S., et al. 2021. Braz J Med Biol Res. 54: e10685. PMID: 34037092
- Tanshinone I Inhibits Oxidative Stress-Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling. | Wu, YT., et al. 2021. Front Pharmacol. 12: 644116. PMID: 34084132
- Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. | Huang, Y., et al. 2021. Theranostics. 11: 6891-6904. PMID: 34093860
- Tanshinone I inhibits metastasis of cervical cancer cells by inducing BNIP3/NIX-mediated mitophagy and reprogramming mitochondrial metabolism. | Cui, S., et al. 2022. Phytomedicine. 98: 153958. PMID: 35124382
- Tanshinone I attenuates fibrosis in fibrotic kidneys through down-regulation of inhibin beta-A. | Wu, M., et al. 2022. BMC Complement Med Ther. 22: 110. PMID: 35439976
- Combined Treatment of Tanshinone I and Epirubicin Revealed Enhanced Inhibition of Hepatocellular Carcinoma by Targeting PI3K/AKT/HIF-1α. | Zhao, J., et al. 2022. Drug Des Devel Ther. 16: 3197-3213. PMID: 36158238
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tanshinone I, 10 mg | sc-205850 | 10 mg | $106.00 | |||
Tanshinone I, 25 mg | sc-205850A | 25 mg | $203.00 |