Molecular structure of Physcion, CAS Number: 521-61-9
Physcion (CAS 521-61-9)
See product citations (7)
Alternate Names:
1,8-Dihydroxy-3-methoxy-6-methylanthraquinone, Emodin-3-methyl ether
Application:
Physcion is an anthraquinone originally isolated from Rheum emodi
CAS Number:
521-61-9
Purity:
≥98%
Molecular Weight:
284.26
Molecular Formula:
C16H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Physcion is a naturally occurring anthraquinone that possesses antifungal and antitumor properties. In addition to its laxative and anti-inflammatory effects, it also inhibits kinases and tyrosinase, and has cytotoxic effects on cancer cells. Physcion has been found to reduce the growth of tumors in mice by inhibiting 6-phosphogluconate dehydrogenase, which decreases lipogenesis and RNA biosynthesis in cancer cells, leading to decreased cell proliferation.
Physcion (CAS 521-61-9) References
- Antifungal activity of anthraquinone derivatives from Rheum emodi. | Agarwal, SK., et al. 2000. J Ethnopharmacol. 72: 43-6. PMID: 10967452
- Physcion induces apoptosis through triggering endoplasmic reticulum stress in hepatocellular carcinoma. | Pan, XP., et al. 2018. Biomed Pharmacother. 99: 894-903. PMID: 29710489
- Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin. | Moon, PD., et al. 2019. Molecules. 24: PMID: 30991764
- Physcion reduces lipid accumulation and prevents the obesity in mice. | Lee, SJ., et al. 2019. Nutr Metab (Lond). 16: 31. PMID: 31123488
- Physcion-Matured Dendritic Cells Induce the Differentiation of Th1 Cells. | Hwang, YH., et al. 2020. Int J Mol Sci. 21: PMID: 32143368
- Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells [Retraction]. | . 2020. Am J Cancer Res. 10: 2687. PMID: 32905419
- Physcion, a tetra-substituted 9,10-anthraquinone, prevents homocysteine-induced endothelial dysfunction by activating Ca2+- and Akt-eNOS-NO signaling pathways. | Ji, XW., et al. 2021. Phytomedicine. 81: 153410. PMID: 33285470
- Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock. | Yao, Y., et al. 2020. Front Pharmacol. 11: 573074. PMID: 33381029
- Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway. | Dong, X., et al. 2021. Drug Des Devel Ther. 15: 277-287. PMID: 33536742
- Physcion Induces Potential Anticancer Effects in Cervical Cancer Cells. | Trybus, W., et al. 2021. Cells. 10: PMID: 34440797
- Microbial production of the plant-derived fungicide physcion. | Qi, F., et al. 2022. Metab Eng. 74: 130-138. PMID: 36328293
- Association of Physcion and Chitosan Can Efficiently Control Powdery Mildew in Rosa roxburghii. | Zhang, C., et al. 2022. Antibiotics (Basel). 11: PMID: 36421305
- Physcion prevents high-fat diet-induced endothelial dysfunction by inhibiting oxidative stress and endoplasmic reticulum stress pathways. | Wang, YH., et al. 2023. Eur J Pharmacol. 943: 175554. PMID: 36709792
- Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection. | Liu, X., et al. 2023. Vet Microbiol. 279: 109664. PMID: 36716634
- A tumor cell growth inhibitor from Polygonum hypoleucum Ohwi. | Kuo, YC., et al. 1997. Life Sci. 61: 2335-44. PMID: 9408056
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Physcion, 10 mg | sc-205805 | 10 mg | $190.00 | |||
Physcion, 25 mg | sc-205805A | 25 mg | $310.00 |