Osthole (CAS 484-12-8)
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Osthole is a coumarin compound that interacts with cellular and molecular components by modulating various signaling pathways. It exerts its effects by inhibiting the activity of certain enzymes, such as acetylcholinesterase, which plays a role in neurotransmission. Osthole has the ability to regulate the expression of genes involved in inflammation and immune responses, thereby influencing cellular processes related to the immune system. Osthole interacts with ion channels, affecting the flow of ions across cell membranes and influencing cellular excitability. Osthole modulates the activity of certain receptors, such as serotonin receptors, which play a role in mood regulation and other physiological processes. Osthole′s mechanism of action involves its ability to interact with a variety of cellular and molecular components, ultimately influencing various cellular processes and pathways.
Osthole (CAS 484-12-8) References
- Osthole prevents tamoxifen-induced liver injury in mice. | Zhou, WB., et al. 2019. Acta Pharmacol Sin. 40: 608-619. PMID: 30315252
- Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms. | Ashrafizadeh, M., et al. 2020. Anticancer Agents Med Chem. 20: 918-931. PMID: 32108003
- Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities. | Zafar, S., et al. 2021. Mini Rev Med Chem. 21: 2747-2763. PMID: 32646359
- Osthole induces necroptosis via ROS overproduction in glioma cells. | Huangfu, M., et al. 2021. FEBS Open Bio. 11: 456-467. PMID: 33350608
- Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice. | Fang, L., et al. 2021. Oxid Med Cell Longev. 2021: 3309944. PMID: 34527170
- Osthole alleviates pulmonary vascular remodeling by modulating microRNA-22-3p mediated lipid metabolic reprogramming. | Niu, Z., et al. 2022. Phytomedicine. 96: 153840. PMID: 34836745
- Protective effect of osthole on testicular ischemia/reperfusion injury in rats. | Kocaman, OH., et al. 2022. Ulus Travma Acil Cerrahi Derg. 28: 563-569. PMID: 35485470
- Osthole Increases the Sensitivity of Liver Cancer to Sorafenib by Inhibiting Cholesterol Metabolism. | Fan, K., et al. 2022. Nutr Cancer. 74: 3640-3650. PMID: 35706361
- Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells. | Wang, J., et al. 2022. Oxid Med Cell Longev. 2022: 8585598. PMID: 35720178
- Effects of osthole on osteoporotic rats: a systematic review and meta-analysis. | Wu, B., et al. 2022. Pharm Biol. 60: 1625-1634. PMID: 35980123
- The coumarin osthole is a non-electrophilic agonist of TRPA1. | Torres, KV., et al. 2022. Neurosci Lett. 789: 136878. PMID: 36115537
- Osthole: An up-to-date review of its anticancer potential and mechanisms of action. | Yang, S., et al. 2022. Front Pharmacol. 13: 945627. PMID: 36160431
- Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway. | Ma, T., et al. 2022. Molecules. 27: PMID: 36500713
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Osthole, 250 mg | sc-205780 | 250 mg | $115.00 | |||
Osthole, 1 g | sc-205780A | 1 g | $280.00 | |||
Osthole, 5 g | sc-205780B | 5 g | $315.00 |