Diosmetin (CAS 520-34-3)
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Diosmetin, a flavonoid compound present in diverse plant sources including citrus fruits, displays notable biological activities. In-depth research has explored diosmetin′s potential applications in scientific investigations. In animal studies, diosmetin exhibits promising anti-inflammatory, anti-tumor, and antioxidant effects. It also shows capabilities against bacteria, viruses, and fungi. Laboratory studies demonstrate its capacity to impede cancer cell growth, mitigate inflammation, and counter oxidative stress.Diosmetin is thought to engage multiple pathways. This involves inhibiting cyclooxygenase-2 (COX-2) enzyme, blocking histone deacetylase (HDAC), and activating the nuclear factor kappa B (NF-κB) pathway. Additionally, it impacts gene expression and enzyme activities. Diosmetin′s biochemical and physiological impacts are diverse. It hampers enzyme actions like COX-2 and HDAC, influences gene expression, and modulates pathways like NF-κB.
Diosmetin (CAS 520-34-3) References
- Diosmetin Targeted at Peroxisome Proliferator-Activated Receptor Gamma Alleviates Advanced Glycation End Products Induced Neuronal Injury. | Lai, MC., et al. 2022. Nutrients. 14: PMID: 35684047
- Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide. | Feldo, M., et al. 2022. Molecules. 27: PMID: 35807509
- Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Dermatitis by Reinforcing Skin Barrier Function through SPINK5/LEKTI Regulation. | Park, NJ., et al. 2022. Int J Mol Sci. 23: PMID: 35955819
- Effect of Date Palm (Phoenix dactylifera) Phytochemicals on Aβ1-40 Amyloid Formation: An in-silico Analysis. | Zia, Q., et al. 2022. Front Neurosci. 16: 915122. PMID: 35958986
- Investigation into the Antihypertensive Effects of Diosmetin and Its Underlying Vascular Mechanisms Using Rat Model. | Ahmad, T., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 36015099
- Investigation into the in vivo mechanism of diosmetin in patients with breast cancer and COVID-19 using bioinformatics. | Wang, J., et al. 2022. Front Pharmacol. 13: 983821. PMID: 36060002
- Suppressive Effects of Flavonoids on Macrophage-Associated Adipocyte Inflammation in a Differentiated Murine Preadipocyte 3T3-L1 Cells Co-Cultured with a Murine Macrophage RAW264.7 Cells. | Lee, D., et al. 2022. Plants (Basel). 11: PMID: 36559664
- Diosmetin inhibits subchondral bone loss and indirectly protects cartilage in a surgically-induced osteoarthritis mouse model. | Ding, H., et al. 2023. Chem Biol Interact. 370: 110311. PMID: 36563736
- Investigation on the Mechanisms of Zanthoxylum bungeanum for Treating Diabetes Mellitus Based on Network Pharmacology, Molecular Docking, and Experiment Verification. | Huang, Y., et al. 2023. Biomed Res Int. 2023: 9298728. PMID: 36874926
- Design of an Herbal Preparation Composed by a Combination of Ruscus aculeatus L. and Vitis vinifera L. Extracts, Magnolol and Diosmetin to Address Chronic Venous Diseases through an Anti-Inflammatory Effect and AP-1 Modulation. | Nocera, R., et al. 2023. Plants (Basel). 12: PMID: 36903912
- Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function. | Xia, J., et al. 2023. Inflammopharmacology. 1-11. PMID: 37074600
- [Diosmetin regulates intestinal immune balance by inhibiting PI3K/AKT signaling to relieve 2, 4, 6-trinitrobenzene sulfonic acid-induced Crohn's disease-like colitis in mice]. | Yang, Z., et al. 2023. Nan Fang Yi Ke Da Xue Xue Bao. 43: 474-482. PMID: 37087594
- Phytoestrogens as Biomarkers of Plant Raw Materials Used for Fish Feed Production. | Pavlopoulos, DT., et al. 2023. Molecules. 28: PMID: 37110857
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diosmetin, 1 g | sc-205653 | 1 g | $189.00 | |||
Diosmetin, 5 g | sc-205653A | 5 g | $867.00 |