Molecular structure of δ-Tocotrienol, CAS Number: 25612-59-3
δ-Tocotrienol (CAS 25612-59-3)
See product citations (1)
Alternate Names:
D-δ-Tocotrienol; (R-(E,E))-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
Application:
δ-Tocotrienol is a particular form of vitamin E
CAS Number:
25612-59-3
Purity:
>98%
Molecular Weight:
396.61
Molecular Formula:
C27H40O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
δ-Tocotrienol is one of the forms of vitamin E (four tocopherols (alpha, beta, delta, and gamma) and four tocotrienols (alpha, beta, delta, and gamma)), which is known for its antioxidant activity. At 0.1-10 muM, delta-tocotrienol significantly suppresses H2O2-induced cell death of rat striatal neurons and provides protection against S-nitrocysteine-induced cell death and SIN-1 cytotoxicity in a concentration dependent manner. At concentrations of 10 muM, delta-tocotrienol displays more inhibitory action on adhesiveness of HAECs to U937 monocytic cells, via inhibition of VCAM-1 expression, than alpha-tocopherol and other tocotrienols at the same concentration.
δ-Tocotrienol (CAS 25612-59-3) References
- Anti-angiogenic activity of tocotrienol. | Inokuchi, H., et al. 2003. Biosci Biotechnol Biochem. 67: 1623-7. PMID: 12913317
- The use of delta-tocotrienol and lovastatin for anti-osteoporotic therapy. | Abdul-Majeed, S., et al. 2015. Life Sci. 125: 42-8. PMID: 25534439
- miR-429 mediates δ-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP. | Wang, C., et al. 2015. Int J Clin Exp Med. 8: 15648-56. PMID: 26629059
- Natural Forms of Vitamin E as Effective Agents for Cancer Prevention and Therapy. | Jiang, Q. 2017. Adv Nutr. 8: 850-867. PMID: 29141970
- δ-Tocotrienol, Isolated from Rice Bran, Exerts an Anti-Inflammatory Effect via MAPKs and PPARs Signaling Pathways in Lipopolysaccharide-Stimulated Macrophages. | Shen, J., et al. 2018. Int J Mol Sci. 19: PMID: 30287730
- δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells. | Fontana, F., et al. 2019. Cell Prolif. 52: e12576. PMID: 30719778
- De Novo High-Titer Production of Delta-Tocotrienol in Recombinant Saccharomyces cerevisiae. | Sun, H., et al. 2020. J Agric Food Chem. 68: 7710-7717. PMID: 32580548
- δ-Tocotrienol induces apoptosis and inhibits proliferation of nasopharyngeal carcinoma cells. | Shen, J., et al. 2021. Food Funct. 12: 6374-6388. PMID: 34056642
- Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells. | Lucci, A., et al. 2022. Can J Physiol Pharmacol. 100: 453-463. PMID: 34932399
- δ-Tocotrienol is the Most Potent Vitamin E Form in Inhibiting Prostate Cancer Cell Growth and Inhibits Prostate Carcinogenesis in Ptenp-/- Mice. | Wang, H., et al. 2022. Cancer Prev Res (Phila). 15: 233-245. PMID: 35144931
- Efficacy of Off-Label Therapy for Non-alcoholic Fatty Liver Disease in Improving Non-invasive and Invasive Biomarkers: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. | Luo, Q., et al. 2022. Front Med (Lausanne). 9: 793203. PMID: 35280867
- Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells. | Pang, KL., et al. 2022. Nutrients. 14: PMID: 36296960
Inhibitor of:
FADS2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
δ-Tocotrienol, 1 mg | sc-205547 | 1 mg | $48.00 | |||
δ-Tocotrienol, 5 mg | sc-205547A | 5 mg | $199.00 |