Molecular structure of Protopanaxatriol, CAS Number: 34080-08-5
Protopanaxatriol (CAS 34080-08-5)
Alternate Names:
20S-Protopanaxatriol
Application:
Protopanaxatriol is a metabolite of ginsenoside
CAS Number:
34080-08-5
Purity:
≥95%
Molecular Weight:
476.73
Molecular Formula:
C30H52O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Protopanaxatriol (PPT) is a polyhydroxy-triterpene that can be found in various medicinal plants. It serves as the primary active compound in ginseng. Although the precise mechanism of action of Protopanaxatriol is not yet fully comprehended, it is believed to engage multiple targets, such as the NF-κB and MAPK pathways. These pathways play pivotal roles in inflammation and cell proliferation. Moreover, it has been observed that Protopanaxatriol inhibits the activity of enzymes implicated in inflammation and cell proliferation.
Protopanaxatriol (CAS 34080-08-5) References
- Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. | Han, KL., et al. 2006. Biol Pharm Bull. 29: 110-3. PMID: 16394521
- Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. | Leung, KW., et al. 2009. Br J Pharmacol. 156: 626-37. PMID: 19226254
- Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-d-aspartic Acid receptor-mediated ion currents. | Shin, TJ., et al. 2012. Korean J Physiol Pharmacol. 16: 113-8. PMID: 22563256
- Protopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice. | Zhang, Y., et al. 2014. Sci Rep. 4: 7375. PMID: 25487878
- Protopanaxatriol inhibits melanin synthesis through inactivation of the pCREB-MITF-tyrosinase signalling pathway in melanocytes. | Lee, CS., et al. 2019. Clin Exp Dermatol. 44: 295-299. PMID: 30194867
- Protective effects of protopanaxatriol on acute liver injury induced by concanavalin A. | Jin, L., et al. 2019. Naunyn Schmiedebergs Arch Pharmacol. 392: 81-87. PMID: 30269219
- Potential Dissociative Glucocorticoid Receptor Activity for Protopanaxadiol and Protopanaxatriol. | Karra, AG., et al. 2018. Int J Mol Sci. 20: PMID: 30591629
- 20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades. | Song, J., et al. 2020. J Agric Food Chem. 68: 8195-8204. PMID: 32662640
- Advances in Saponin Diversity of Panax ginseng. | Piao, X., et al. 2020. Molecules. 25: PMID: 32751233
- Pharmacological potential of ginseng and its major component ginsenosides. | Ratan, ZA., et al. 2021. J Ginseng Res. 45: 199-210. PMID: 33841000
- Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes. | Lee, JO., et al. 2021. J Ginseng Res. 45: 354-360. PMID: 33841016
- Integrated Metabolomics and Network Pharmacology to Decipher the Latent Mechanisms of Protopanaxatriol against Acetic Acid-Induced Gastric Ulcer. | Wang, C., et al. 2022. Int J Mol Sci. 23: PMID: 36292949
- Production of a Novel Protopanaxatriol-Type Ginsenoside by Yeast Cell Factories. | Zhou, C., et al. 2023. Bioengineering (Basel). 10: PMID: 37106650
Activator of:
PSK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Protopanaxatriol, 5 mg | sc-204866 | 5 mg | $180.00 | |||
Protopanaxatriol, 10 mg | sc-204866A | 10 mg | $193.00 |