Molecular structure of Limonin, CAS Number: 1180-71-8
Limonin (CAS 1180-71-8)
Alternate Names:
Limonoic acid di-δ-lactone; Limonoic acid 3,19:16,17 dilactone
Application:
Limonin is a chemically induced carcinogenesis inhibitor
CAS Number:
1180-71-8
Purity:
≥98%
Molecular Weight:
470.52
Molecular Formula:
C26H30O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Limonin, a prominent compound found in citrus fruits, is renowned for its significant role in various research fields, particularly due to its properties as an inhibitor of chemically-induced carcinogenesis and HIV-1 replication. This natural compound has been extensively studied for its ability to interfere with specific biochemical pathways that lead to the development of cancer, showcasing a potential for influencing cell proliferation and apoptosis mechanisms in a way that impedes tumor growth and progression.
Limonin (CAS 1180-71-8) References
- Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. | Tanaka, T., et al. 2000. Biofactors. 13: 213-8. PMID: 11237184
- Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. | Battinelli, L., et al. 2003. Planta Med. 69: 910-3. PMID: 14648393
- Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside. | Breksa, AP. and Manners, GD. 2006. J Agric Food Chem. 54: 3827-31. PMID: 16719503
- The effect of citrus limonoids on hamster buccal pouch carcinogenesis. | Miller, EG., et al. 1989. Carcinogenesis. 10: 1535-7. PMID: 2502323
- Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics. | Fan, S., et al. 2019. Molecules. 24: PMID: 31614806
- Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-κB inflammatory response via upregulating Sirt1. | Yang, R., et al. 2020. Phytomedicine. 69: 153211. PMID: 32259676
- Limonin suppresses the progression of oral tongue squamous cell carcinoma via inhibiting YAP transcriptional regulatory activity. | Yang, G., et al. 2020. Tissue Cell. 65: 101346. PMID: 32746992
- Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway. | Yang, R., et al. 2021. J Agric Food Chem. 69: 982-991. PMID: 33427450
- Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity. | Chen, Y., et al. 2021. Food Sci Nutr. 9: 1860-1869. PMID: 33841805
- Limonin Alleviates Non-alcoholic Fatty Liver Disease by Reducing Lipid Accumulation, Suppressing Inflammation and Oxidative Stress. | Li, Y., et al. 2021. Front Pharmacol. 12: 801730. PMID: 35046824
- Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway. | Chen, J., et al. 2020. Transl Cancer Res. 9: 6820-6832. PMID: 35117291
- Limonin, an AMPK Activator, Inhibits Hepatic Lipid Accumulation in High Fat Diet Fed Mice. | Wang, SW., et al. 2022. Front Pharmacol. 13: 833705. PMID: 35140621
- Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy. | Liu, LB., et al. 2022. Br J Pharmacol. 179: 4516-4533. PMID: 35727596
- Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells. | Kang, JI., et al. 2022. Nutrients. 14: PMID: 36558517
- Antinociceptive and anti-inflammatory activities of limonin isolated from the fruits of Evodia rutaecarpa var. bodinieri. | Matsuda, H., et al. 1998. Planta Med. 64: 339-42. PMID: 9619117
Inhibitor of:
C8orf79_6430573F11Rik, and TLR5.Activator of:
EG623186.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Limonin, 50 mg | sc-204793 | 50 mg | $66.00 | |||
Limonin, 100 mg | sc-204793A | 100 mg | $82.00 | |||
Limonin, 500 mg | sc-204793B | 500 mg | $326.00 |