Molecular structure of Diacerein, CAS Number: 13739-02-1
Diacerein (CAS 13739-02-1)
See product citations (2)
Alternate Names:
1,8-Diacetoxy-3-carboxyanthraquinone
Application:
Diacerein is a tricyclic psuedo-phenanthrene showing interleukin-1 inhibition
CAS Number:
13739-02-1
Purity:
≥98%
Molecular Weight:
368.30
Molecular Formula:
C19H12O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diacerein is a chemical compound that functions as an inhibitor of interleukin-1 beta. It exerts its mechanism of action by inhibiting the production of interleukin-1 beta, a pro-inflammatory cytokine that plays a role in the inflammatory response. By targeting this specific cytokine, diacerein can modulate the inflammatory process at the molecular level. Diacerein interferes with the signaling pathways involved in the production of interleukin-1 beta, thereby reducing its levels and potentially impacting downstream inflammatory processes. In experimental applications, diacerein′s mechanism of action involves its ability to target and inhibit the activity of interleukin-1 beta, contributing to the modulation of inflammatory responses at the cellular and molecular levels.
Diacerein (CAS 13739-02-1) References
- [Effectiveness of drugs used in degenerative joint diseases (arthroses)]. | Sanfélix-Gimeno, G., et al. 2008. Med Clin (Barc). 130: 463-5. PMID: 18405503
- An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK). | Sharma, A., et al. 2008. J Indian Med Assoc. 106: 54-6, 58. PMID: 18705272
- OARSI guidelines for the non-surgical management of knee osteoarthritis. | McAlindon, TE., et al. 2014. Osteoarthritis Cartilage. 22: 363-88. PMID: 24462672
- Cocrystals of diacerein: Towards the development of improved biopharmaceutical parameters. | Tomar, S., et al. 2020. Int J Pharm. 574: 118942. PMID: 31830577
- Diacerein treatment prevents colitis-associated cancer in mice. | Paulino, DSM., et al. 2020. World J Clin Oncol. 11: 732-746. PMID: 33033695
- Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell. | Tien, PT., et al. 2021. Mediators Inflamm. 2021: 6660640. PMID: 34285659
- Diacerein attenuates vascular dysfunction by reducing inflammatory response and insulin resistance in type 2 diabetic rats. | He, A., et al. 2021. Biochem Biophys Res Commun. 585: 68-74. PMID: 34801936
- Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation. | Barakat, N., et al. 2021. Saudi J Biol Sci. 28: 7219-7226. PMID: 34867025
- Diacerein versus adipoRon as adiponectin modulators in experimentally-induced end-stage type 2 diabetes mellitus in rats. | Samaha, MM., et al. 2022. Environ Toxicol Pharmacol. 90: 103806. PMID: 34974166
- Reversal of Epigenetic Peroxisome Proliferator-Activated Receptor-γ Suppression by Diacerein Alleviates Oxidative Stress and Osteoarthritis in Mice. | Chen, X., et al. 2022. Antioxid Redox Signal. 37: 40-53. PMID: 35196878
- Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1β and IL-4/MCP-1 signaling pathways. | Elshal, M. and Abdelmageed, ME. 2022. Arch Pharm Res. 45: 142-158. PMID: 35244883
- Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal. | Mohamed Kamel, GA., et al. 2022. Mol Biol Rep. 49: 5863-5874. PMID: 35366176
- Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats. | Ibrahim, YF., et al. 2022. Biomed Pharmacother. 149: 112870. PMID: 35367769
- Diacerein alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs/c-Myc pathway. | Wang, M., et al. 2022. Phytomedicine. 106: 154387. PMID: 36027716
- Diacerein protects liver against APAP-induced injury via targeting JNK and inhibiting JNK-mediated oxidative stress and apoptosis. | Wang, M., et al. 2022. Biomed Pharmacother. 149: 112917. PMID: 36068777
Inhibitor of:
IL-1, IL-1F10, IL-1ra, IL1F6, and Lubricin.Activator of:
CHAD, and Matrilin-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diacerein, 50 mg | sc-204717 | 50 mg | $120.00 | |||
Diacerein, 250 mg | sc-204717A | 250 mg | $544.00 |