Molecular structure of Climbazole, CAS Number: 38083-17-9
Climbazole (CAS 38083-17-9)
Application:
Climbazole is a potent inducer and inhibitor of P450-dependent metabolizing enzymes
CAS Number:
38083-17-9
Purity:
98%
Molecular Weight:
292.76
Molecular Formula:
C15H17ClN2O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Climbazole functions as an antifungal agent. Its mechanism of action involves inhibiting the growth of fungi by disrupting the synthesis of ergosterol. This disruption leads to increased permeability of the cell membrane, ultimately causing the death of the fungal cells. Climbazole targets and inhibits the enzyme cytochrome P450 14α-demethylase, which is involved in the biosynthesis of ergosterol. By interfering with this key enzyme, climbazole effectively disrupts the fungal cell membrane structure, leading to its antifungal activity. This mechanism of action makes climbazole useful in studying fungal cell biology and developing potential antifungal strategies.
Climbazole (CAS 38083-17-9) References
- Climbazole is a new potent inducer of rat hepatic cytochrome P450. | Kobayashi, Y., et al. 2001. J Toxicol Sci. 26: 141-50. PMID: 11552297
- Induction and inhibition of cytochrome P450 and drug-metabolizing enzymes by climbazole. | Kobayashi, Y., et al. 2002. Biol Pharm Bull. 25: 53-7. PMID: 11824557
- Rheology of Dead Sea shampoo containing the antidandruff climbazole. | Abu-Jdayil, B. and Mohameed, HA. 2004. Int J Cosmet Sci. 26: 281-9. PMID: 18492152
- Evaluation of the genotoxicity of the imidazole antifungal climbazole: comparison to published results for other azole compounds. | Pérez-Rivera, AA., et al. 2009. Mutat Res. 672: 27-39. PMID: 18950734
- Occurrence and dissipation of three azole biocides climbazole, clotrimazole and miconazole in biosolid-amended soils. | Chen, ZF., et al. 2013. Sci Total Environ. 452-453: 377-83. PMID: 23542433
- Ecotoxicity of climbazole, a fungicide contained in antidandruff shampoo. | Richter, E., et al. 2013. Environ Toxicol Chem. 32: 2816-25. PMID: 23982925
- Climbazole increases expression of cornified envelope proteins in primary keratinocytes. | Pople, JE., et al. 2014. Int J Cosmet Sci. 36: 419-26. PMID: 24811958
- Multimedia fate modeling and risk assessment of a commonly used azole fungicide climbazole at the river basin scale in China. | Zhang, QQ., et al. 2015. Sci Total Environ. 520: 39-48. PMID: 25794970
- Topical delivery of climbazole to mammalian skin. | Paz-Alvarez, M., et al. 2018. Int J Pharm. 549: 317-324. PMID: 30055301
- Degradation of climbazole by UV/chlorine process: Kinetics, transformation pathway and toxicity evaluation. | Cai, WW., et al. 2019. Chemosphere. 219: 243-249. PMID: 30543959
- Analysis of transcriptional response in zebrafish eleutheroembryos exposed to climbazole: Signaling pathways and potential biomarkers. | Zhang, H., et al. 2019. Environ Toxicol Chem. 38: 794-805. PMID: 30614048
- A validated LC-MS/MS method for the quantification of climbazole metabolites in human urine. | Schmidtkunz, C., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1173: 122677. PMID: 33848799
- Characterization of Climbazole-Bovine serum albumin interaction by experimental and in silico approaches. | Zahirul Kabir, M., et al. 2023. Spectrochim Acta A Mol Biomol Spectrosc. 288: 122197. PMID: 36470090
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Climbazole, 5 g | sc-204691 | 5 g | $71.00 | |||
Climbazole, 10 g | sc-204691A | 10 g | $99.00 |