Molecular structure of Bezafibrate, CAS Number: 41859-67-0
Bezafibrate (CAS 41859-67-0)
See product citations (5)
Alternate Names:
Cedur
Application:
Bezafibrate is a peroxisome proliferator and hypolipidaemic agent
CAS Number:
41859-67-0
Purity:
≥98%
Molecular Weight:
361.82
Molecular Formula:
C19H20ClNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Bezafibrate is a compound widely used in research focused on lipid metabolism and energy homeostasis. It acts as an agonist for peroxisome proliferator-activated receptors (PPARs), which are instrumental in the regulation of lipid levels and are targets for the study of metabolic disorders. In cellular and molecular biology research, bezafibrate is employed to examine the transcriptional regulation of genes involved in fatty acid oxidation and cholesterol metabolism. It is also studied in the context of its effects on mitochondrial biogenesis and function, as PPAR activation is known to influence these processes. Additionally, bezafibrate′s role in modulating the expression of apolipoproteins is of interest in understanding the pathophysiology of dyslipidemia and atherosclerosis.
Bezafibrate (CAS 41859-67-0) References
- Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: a preliminary study. | Nakai, S., et al. 2000. Am J Gastroenterol. 95: 326-7. PMID: 10638623
- Peroxisome proliferators induce apoptosis and decrease DNA synthesis in hepatoma cell lines. | Goll, V., et al. 2000. Hum Exp Toxicol. 19: 193-202. PMID: 10889518
- Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate. | Kyrklund, C., et al. 2001. Clin Pharmacol Ther. 69: 340-5. PMID: 11372002
- Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: reversal with bezafibrate therapy in a randomized controlled trial. | Jonkers, IJ., et al. 2002. Am J Med. 112: 275-80. PMID: 11893366
- Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate. | Holzgartner, H., et al. 1992. Arzneimittelforschung. 42: 1473-7. PMID: 1288512
- Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. | Tenenbaum, A., et al. 2005. Cardiovasc Diabetol. 4: 14. PMID: 16168052
- Attenuation of progression of insulin resistance in patients with coronary artery disease by bezafibrate. | Tenenbaum, A., et al. 2006. Arch Intern Med. 166: 737-41. PMID: 16606809
- Bezafibrate removal by means of ozonation: primary intermediates, kinetics, and toxicity assessment. | Dantas, RF., et al. 2007. Water Res. 41: 2525-32. PMID: 17467033
- Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice. | Yatsuga, S. and Suomalainen, A. 2012. Hum Mol Genet. 21: 526-35. PMID: 22012983
- Bezafibrate in skeletal muscle fatty acid oxidation disorders: a randomized clinical trial. | Ørngreen, MC., et al. 2014. Neurology. 82: 607-13. PMID: 24453079
- Prospective study of bezafibrate for the treatment of primary sclerosing cholangitis. | Mizuno, S., et al. 2015. J Hepatobiliary Pancreat Sci. 22: 766-70. PMID: 26173026
- Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects. | Heller, F. and Harvengt, C. 1983. Eur J Clin Pharmacol. 25: 57-63. PMID: 6617725
- The short- and long-term effects of bezafibrate in the rat. | Fahimi, HD., et al. 1982. Ann N Y Acad Sci. 386: 111-35. PMID: 6953842
- The effect of bezafibrate treatment on serum alkaline phosphatase isoenzyme activities. | Day, AP., et al. 1993. Metabolism. 42: 839-42. PMID: 8102192
- Chemoprevention of radiation-induced mammary tumors in rats by bezafibrate administered together with diethylstilbestrol as a promoter. | Inano, H., et al. 1996. Carcinogenesis. 17: 2641-6. PMID: 9006101
Inhibitor of:
ABCD1, ACOT4, ACOX3, Angptl7, arginase II, ATP5SL, Ces1a, CYP17A1, Dbil5, DSCD75, Endothelial Lipase, GGPL-I, HAO1, LIP1, LPL, MDGI, mitoNEET, NDUFB3, PDC-E2, PDSS2, Peroxin 11α, Pex5p, Pex7p, QIL1, SERAC1, SUCLG2, Tafazzin, and TMEM70.Activator of:
17β-HSD11, 17β-HSD13, 2310042D19Rik, 2900097C17Rik, A-FABP, ABCD2, ABHD10, ABHD14A, ABHD5, Acaa1b, ACAD-10, ACAD-11, ACAD-8, ACAD-9, ACADSB, ACOT1, ACOT5, ACOT6, ACOT9, ACOX1, ACOX2, ACOXL, ACSBG2, ACSF1, ACSF3, ACSL1, ACSL6, ACSM2B, ACSM3, ACSM5, AKR1CL2, Angptl3, Angptl5, apoM, apoOL, ATAD1, ATAD3B, ATP10A, ATP10D, ATP11, ATPAF2, BFZB, C11orf83, C3orf60, C4orf14, C6orf167, CDV, Ces1a, Ces1d, CHCHD3, CHCHD6, Cholesterol Esterase, CLS1, COQ4, COX10, COX18, COX20, COX4, COX7b, COX7b2, COX7c, CPTII, CROT, CTRP2, CYP4A1, CYP4A10, CYP4A11, CYP4A22, Cyp4f39, Cyp4f40, CYP4V3, Dbil5, DECR2, DGUOK, DNA pol γ2, DSCD75, E-FABP, ECH1, ECHDC3, EG435927, EG624219, EHHADH, ERAL1, ETFA, FACL5, FACL6, FADS2, FASTKD2, FASTKD5, FATP-1, FATP4, FIC1, GABP-β2, GK3P, Gm749, HADHA, HADHB, HAL, HARS2, Hepatic Lipase, HIBCH, HNF-4B, I-FABP, ICT1, KIAA0664, L-FABP, Lipin-2, Lipin-3, Lipocalin-11, LIPT2, LPD lipase, LPL, LYRM9, Maltase-glucoamylase, MBOAT4, MCAD, Mecr, Mfn2, MINOS1, Mitochondrial Topo I, Mitofilin, MPC1L, MPV17, MRM1, MRP-63, MRP-L13, MRP-L14, MRP-L15, MRP-L17, MRP-L18, MRP-L19, MRP-L2, MRP-L24, MRP-L27, MRP-L28, MRP-L3, MRP-L35, MRP-L37, MRP-L40, MRP-L45, MRP-L46, MRP-L49, MRP-L52, MRP-L54, MRP-L55, MRP-S10, MRP-S12, MRP-S21, MRP-S25, MRP-S26, MRP-S27, MRP-S34, MRP-S36, MRP-S6, mt-TyrRS, MTP, MTP18, MtRPOL, mtTFA, MUP, ND5, ND6, NDUFA11, NDUFA7, NDUFAF1, NDUFB10, NDUFB5, NDUFB7, NDUFS3, OXA1L, Paraplegin, PARS2, PECI, Peroxin 11γ, Peroxin 12, Peroxin 13, Peroxin 14, Peroxin 16, Peroxin 2, Peroxin 3, Peroxin 5, Peroxin 5R, Peroxin 7, Peroxisome 26, PET100, PGS1, PHYH, Pmp24, PNP2, PPAN, PPAR alpha, PPAR beta, PPAR gamma, PRELI, PTCD1, pUb-R, Pxmp2, QIL1, RARS2, RPUSD2, SLC25A14, SLC25A20, SLC25A35, SLC25A42, SLC25A43, SLC25A44, TARSL1, TFB1M, Tim13B, Tim14, Tim23B, TMEM126A, TMEM135, TMEM70, Tom23, Tomm5, TYSND1, UQCRC2, USP30, and WARS2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bezafibrate, 500 mg | sc-204650B | 500 mg | $30.00 | |||
Bezafibrate, 1 g | sc-204650 | 1 g | $45.00 | |||
Bezafibrate, 5 g | sc-204650A | 5 g | $120.00 | |||
Bezafibrate, 10 g | sc-204650C | 10 g | $200.00 |