Date published: 2025-9-5

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Betamethasone (CAS 378-44-9)

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Alternate Names:
Becort; Celestene; Flubenisolone
Application:
Betamethasone is a glucocorticoid that induces gene expression and apoptosis
CAS Number:
378-44-9
Purity:
≥98%
Molecular Weight:
392.46
Molecular Formula:
C22H29FO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Betamethasone is a glucocorticoid that induces gene expression and apoptosis. Betamethasone is an activates the glucocorticoid receptor (GR).


Betamethasone (CAS 378-44-9) References

  1. Pimecrolimus does not affect the differentiation, maturation and function of human monocyte-derived dendritic cells, in contrast to corticosteroids.  |  Kalthoff, FS., et al. 2003. Clin Exp Immunol. 133: 350-9. PMID: 12930360
  2. Solid lipid nanoparticles-loaded topical gel containing combination drugs: an approach to offset psoriasis.  |  Sonawane, R., et al. 2014. Expert Opin Drug Deliv. 11: 1833-47. PMID: 25078031
  3. Superior efficacy of calcipotriene and betamethasone dipropionate aerosol foam versus ointment in patients with psoriasis vulgaris--A randomized phase II study.  |  Koo, J., et al. 2016. J Dermatolog Treat. 27: 120-7. PMID: 26444907
  4. Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival.  |  Peranteau, WH., et al. 2016. J Pediatr Surg. 51: 28-32. PMID: 26526208
  5. Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis.  |  Lovato, P., et al. 2016. J Dermatol Sci. 81: 153-64. PMID: 26794805
  6. Effect of antenatal betamethasone on blood glucose levels in women with and without diabetes.  |  Jolley, JA., et al. 2016. Diabetes Res Clin Pract. 118: 98-104. PMID: 27351800
  7. Calcipotriol plus betamethasone dipropionate aerosol foam provides superior efficacy vs. gel in patients with psoriasis vulgaris: randomized, controlled PSO-ABLE study.  |  Paul, C., et al. 2017. J Eur Acad Dermatol Venereol. 31: 119-126. PMID: 27531752
  8. Low-dose betamethasone-acetate for fetal lung maturation in preterm sheep.  |  Schmidt, AF., et al. 2018. Am J Obstet Gynecol. 218: 132.e1-132.e9. PMID: 29138038
  9. Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): a multicentre, double-blind, randomised controlled trial.  |  Crowther, CA., et al. 2019. Lancet Child Adolesc Health. 3: 769-780. PMID: 31523039
  10. Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India.  |  Jobe, AH., et al. 2020. Clin Transl Sci. 13: 391-399. PMID: 31808984
  11. Calcipotriol/betamethasone dipropionate formulations for psoriasis: an overview of the options and efficacy data.  |  Megna, M., et al. 2020. Expert Rev Clin Immunol. 16: 599-620. PMID: 32476507
  12. Dexamethasone versus betamethasone for preterm birth: a systematic review and network meta-analysis.  |  Ciapponi, A., et al. 2021. Am J Obstet Gynecol MFM. 3: 100312. PMID: 33482400
  13. Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate.  |  Takahashi, T., et al. 2022. Am J Obstet Gynecol. 226: 564.e1-564.e14. PMID: 34626553
  14. Spotlight on Calcipotriol/Betamethasone Fixed-Dose Combination in Topical Formulations: Is There Still Room for Innovation?  |  Selmin, F., et al. 2022. Pharmaceutics. 14: PMID: 36297520
  15. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription.  |  Hofmann, TG., et al. 1998. FEBS Lett. 441: 441-6. PMID: 9891987

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Betamethasone, 100 mg

sc-204647
100 mg
$160.00

Betamethasone, 500 mg

sc-204647A
500 mg
$555.00