Molecular structure of Gedunin, CAS Number: 2753-30-2
Gedunin (CAS 2753-30-2)
See product citations (8)
Alternate Names:
(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
Application:
Gedunin is an Hsp90 inhibitor
CAS Number:
2753-30-2
Purity:
>98%
Molecular Weight:
482.57
Molecular Formula:
C28H34O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gedunin is a naturally occurring Hsp90 inhibitor. In vitro, Gedunin induces Hsp90-dependent client protein degradation and displays antiproliferative activity (IC50 values are 3.22, 8.84 and 16.8 muM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Gedunin exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 muM in parasite development and [3H]-hypoxanthine uptake assays respectively).
Gedunin (CAS 2753-30-2) References
- Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. | Uddin, SJ., et al. 2007. Phytother Res. 21: 757-61. PMID: 17450509
- Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). | Lee, SE., et al. 2008. Phytomedicine. 15: 533-5. PMID: 17913482
- Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. | Brandt, GE., et al. 2008. J Med Chem. 51: 6495-502. PMID: 18816111
- Gedunin, a natural tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation. | Ferraris, FK., et al. 2012. Int Immunopharmacol. 14: 82-93. PMID: 22709475
- Effect of gedunin on acute articular inflammation and hypernociception in mice. | Conte, FP., et al. 2015. Molecules. 20: 2636-57. PMID: 25654532
- Gedunin abrogates aldose reductase, PI3K/Akt/mToR, and NF-κB signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis. | Kishore T, KK., et al. 2016. Tumour Biol. 37: 2083-93. PMID: 26342697
- Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway. | Subramani, R., et al. 2017. Oncotarget. 8: 10891-10904. PMID: 26988754
- Gedunin Inhibits Oligomeric Aβ1-42-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling. | Tom, S., et al. 2019. Mol Neurobiol. 56: 7851-7862. PMID: 31127528
- Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis. | Sahai, R., et al. 2020. Apoptosis. 25: 481-499. PMID: 32399945
- Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy. | Hasan, A., et al. 2020. Life Sci. 256: 118000. PMID: 32585246
- Importance of Gedunin in Antagonizing Rheumatoid Arthritis via Activating the Nrf2/ARE Signaling. | Chen, JY., et al. 2022. Oxid Med Cell Longev. 2022: 6277760. PMID: 35432723
- Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells. | Zhou, H., et al. 2022. Appl Biochem Biotechnol. 194: 5322-5332. PMID: 35759172
- Identification of Gedunin from a Phytochemical Depository as a Novel Multidrug Resistance-Bypassing Tubulin Inhibitor of Cancer Cells. | Khalid, SA., et al. 2022. Molecules. 27: PMID: 36144591
- Concise Chemoenzymatic Synthesis of Gedunin. | Li, J., et al. 2022. J Am Chem Soc. 144: 19238-19242. PMID: 36222746
- Molecular Property Prediction of Modified Gedunin Using Machine Learning. | Aly, M. and Alotaibi, AS. 2023. Molecules. 28: PMID: 36770791
Inhibitor of:
Cdc37, HSF1, and HSP 90.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gedunin, 1 mg | sc-203967 | 1 mg | $195.00 |