Molecular structure of Chlorhexidine, Dihydrochloride, CAS Number: 3697-42-5
Chlorhexidine, Dihydrochloride (CAS 3697-42-5)
See product citations (6)
Application:
Chlorhexidine, Dihydrochloride is an anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9
CAS Number:
3697-42-5
Purity:
≥95%
Molecular Weight:
578.37
Molecular Formula:
C22H30Cl2N10•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chlorhexidine, Dihydrochloride is an anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9 metalloproteinases. However, MMP-2 is more sensitive to chlorhexidine than MMP-9. Chlorhexidine, dihydrochloride inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. Chlorhexidine, dihydrochloride may possibly act through a cation-chelating mechanism.
Chlorhexidine, Dihydrochloride (CAS 3697-42-5) References
- Curative effect of chlorhexidine dihydrochloride in experimental amoebiasis of rat and its cysticidal property. | DAS, SR., et al. 1963. Ann Biochem Exp Med. 23: 57-60. PMID: 14025184
- The application of modified flow-through cell apparatus for the assessment of chlorhexidine dihydrochloride release from lozenges containing sorbitol. | Musial, W. and Mielck, JB. 2009. AAPS PharmSciTech. 10: 1048-57. PMID: 19669894
- Pharmacological targeting of the mitochondrial phosphatase PTPMT1. | Doughty-Shenton, D., et al. 2010. J Pharmacol Exp Ther. 333: 584-92. PMID: 20167843
- Sustained in vitro activity of human albumin microspheres containing chlorhexidine dihydrochloride against bacteria from cultures of organisms that cause urinary tract infections. | Egbaria, K. and Friedman, M. 1990. Antimicrob Agents Chemother. 34: 2118-21. PMID: 2127344
- Synthesis of thiazole derivatives and evaluation of their antiamoebic activity and cytotoxicity. | Shirai, A., et al. 2013. Biocontrol Sci. 18: 183-91. PMID: 24366623
- Diminished Antimicrobial Peptide and Antifungal Antibiotic Activities against Candida albicans in Denture Adhesive. | Bates, AM., et al. 2017. Antibiotics (Basel). 6: PMID: 28178179
- Crystalline Polymorphism Emerging From a Milling-Induced Amorphous Form: The Case of Chlorhexidine Dihydrochloride. | Elisei, E., et al. 2018. J Pharm Sci. 107: 121-126. PMID: 28716502
- Association, Distribution, Liberation, and Rheological Balances of Alkyldimethylbenzylammonium Chlorides (C12-C16). | Vitková, Z., et al. 2017. Molecules. 22: PMID: 29073737
- ent-Copalic acid antibacterial and anti-biofilm properties against Actinomyces naeslundii and Peptostreptococcus anaerobius. | Souza, MGM., et al. 2018. Anaerobe. 52: 43-49. PMID: 29885640
- In-situ forming implants loaded with chlorhexidine and ibuprofen for periodontal treatment: Proof of concept study in vivo. | Batool, F., et al. 2019. Int J Pharm. 569: 118564. PMID: 31352049
- Characterization and Molecular Modelling of Non-Antibiotic Nanohybrids for Wound Healing Purposes. | Valentino, C., et al. 2023. Pharmaceutics. 15: PMID: 37111626
- Study on antibacterial root canal sealer containing chlorhexidine dihydrochloride. II. Investigation of antibacterial activity and follow-up study on clinical usage. | Nambu, T. 1984. Dent Mater J. 3: 288-311. PMID: 6597747
- Effects of chlorhexidine dihydrochloride in the diet on caries in hamsters. | Gaffar, A. and Marcussen, HW. 1980. Caries Res. 14: 84-9. PMID: 6927969
Inhibitor of:
MMP-2, and MMP-9.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chlorhexidine, Dihydrochloride, 100 mg | sc-203886 | 100 mg | $26.00 |