Molecular structure of Phloxine B, CAS Number: 18472-87-2
Phloxine B (CAS 18472-87-2)
See product citations (1)
Alternate Names:
Acid Red 92; Cyanosine
Application:
Phloxine B is a fluorescein photoactive dye
CAS Number:
18472-87-2
Molecular Weight:
829.63
Molecular Formula:
C20H2Br4Cl4Na2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phloxine B is a phenyl-xanthene dye which is known to inhibit the enzyme UDP-glucuronosyltransferase (UGT), the main catalyst for the glucuronidation of 7-HC. Additionally, Phloxine B is reported to be a poly(ADP-ribose) glycohydrolase (PARG)inhibitor. As a photoactive dye reported to have efficacy against gram-positive organisms. Phloxine B has also brrn utilized in a study investigating the visible light-induced photodegradation kinetics when coated onto silica TLC plates and in solution. The rapid photodegradation of Phloxine B via visible light exposure was noted and the phototoxicity of the remaining residues were also reported to be decreased.
Phloxine B (CAS 18472-87-2) References
- Phloxine B interacts with the cystic fibrosis transmembrane conductance regulator at multiple sites to modulate channel activity. | Cai, Z. and Sheppard, DN. 2002. J Biol Chem. 277: 19546-53. PMID: 11904291
- Pro-oxidant action of phloxine B on fission yeast Schizosaccharomyces pombe. | Mutoh, N., et al. 2005. Yeast. 22: 91-7. PMID: 15645504
- Phloxine B, a versatile bacterial stain. | Rasooly, R. 2007. FEMS Immunol Med Microbiol. 49: 261-5. PMID: 17328759
- Visible light induced photodegradation and phototoxicity of phloxine B and uranine. | Wang, H., et al. 2008. Biomed Environ Sci. 21: 438-41. PMID: 19133619
- Photodynamic treatment: a novel method for sanitation of food handling and food processing surfaces. | Brovko, LY., et al. 2009. J Food Prot. 72: 1020-4. PMID: 19517729
- Provision of 'comprehensive dental care' in various dental schools. | Slabbert, JC., et al. 1990. J Esthet Dent. 2: 177-80. PMID: 2088435
- On-line HPLC analysis system for metabolism and inhibition studies in precision-cut liver slices. | van Midwoud, PM., et al. 2011. Anal Chem. 83: 84-91. PMID: 21128611
- Phloxine B as a probe for entrapment in microcrystalline cellulose. | Duarte, P., et al. 2012. Molecules. 17: 1602-16. PMID: 22314381
- Ascorbic acid synergistically potentiates phloxine b-induced photocytotoxicity in human acute promyelocytic leukemia cells. | Qi, H., et al. 2014. J Biochem Mol Toxicol. 28: 167-73. PMID: 24488945
- Low concentration Phloxine B staining for high chemical contrast, nonlinear microscope mosaic imaging of skin alterations in pseudoxanthoma elasticum. | Fésűs, L., et al. 2022. Biomed Opt Express. 13: 252-261. PMID: 35154868
Inhibitor of:
PARG, and UGT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phloxine B, 25 g | sc-203753 | 25 g | $57.00 | |||
Phloxine B, 100 g | sc-203753A | 100 g | $159.00 | |||
Phloxine B, 250 g | sc-203753B | 250 g | $292.00 | |||
Phloxine B, 1 kg | sc-203753C | 1 kg | $904.00 |