Molecular structure of Costunolide, CAS Number: 553-21-9
Costunolide (CAS 553-21-9)
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Alternate Names:
(3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one
Application:
Costunolide is a sequiterpene lactone that inhibits telomerase
CAS Number:
553-21-9
Purity:
≥98%
Molecular Weight:
232.32
Molecular Formula:
C15H20O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway.
Costunolide (CAS 553-21-9) References
- Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. | Jeong, SJ., et al. 2002. Cancer Lett. 187: 129-33. PMID: 12359360
- Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. | Choi, SH., et al. 2005. Cancer Lett. 227: 153-62. PMID: 16112418
- Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation. | Choi, JH. and Lee, KT. 2009. Biol Pharm Bull. 32: 1803-8. PMID: 19801848
- Antioxidant activity of costunolide and eremanthin isolated from Costus speciosus (Koen ex. Retz) Sm. | Eliza, J., et al. 2010. Chem Biol Interact. 188: 467-72. PMID: 20709041
- Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential. | Kim, DY. and Choi, BY. 2019. Int J Mol Sci. 20: PMID: 31208018
- Costunolide ameliorates colitis via specific inhibition of HIF1α/glycolysis-mediated Th17 differentiation. | Lv, Q., et al. 2021. Int Immunopharmacol. 97: 107688. PMID: 33932695
- Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer. | Tian, X., et al. 2022. Mol Cancer. 21: 193. PMID: 36203195
- Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. | Xu, H., et al. 2023. Acta Pharm Sin B. 13: 678-693. PMID: 36873170
- Costunolide attenuates LPS-induced inflammation and lung injury through inhibiting IKK/NF-κB signaling. | Zhu, X., et al. 2024. Naunyn Schmiedebergs Arch Pharmacol. 397: 1601-1610. PMID: 37688623
- Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii. | Park, HJ., et al. 1996. J Nat Prod. 59: 1128-30. PMID: 8988596
Inhibitor of:
Est1, NOS, PINX1, RTEL1, TEN1, TP1, and TRT.Activator of:
TP1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Costunolide, 1 mg | sc-203555 | 1 mg | $81.00 | |||
Costunolide, 10 mg | sc-203555A | 10 mg | $168.00 |