Molecular structure of Acarbose, CAS Number: 56180-94-0
Acarbose (CAS 56180-94-0)
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Alternate Names:
Acarbose is also known as BAY-g 5421.
Application:
Acarbose is an α-glucosidase inhibitor that can function as an anti-diabetic by preventing absorption of sucrose and maltose.
CAS Number:
56180-94-0
Purity:
≥97%
Molecular Weight:
645.61
Molecular Formula:
C25H43NO18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acarbose is a pseudo-tetrasaccharide widely utilized in biochemical research for its alpha-glucosidase inhibitory action, offering a window into carbohydrate metabolism processes. It is particularly valuable in enzymology, where it helps delineate the mechanism of enzyme inhibition, enzyme-substrate specificity, and the kinetics of carbohydrate-processing enzymes. Additionally, the compound′s role in the modification of polysaccharide metabolism is leveraged in industrial biotechnology research to enhance the yield of bioconversion processes. Acarbose also serves as a molecular tool in microbiology to explore the biosynthesis of natural glycosidic compounds, aiding in the discovery of novel enzymes and metabolic pathways.
Acarbose (CAS 56180-94-0) References
- Acarbose in the prevention of cardiovascular disease in subjects with impaired glucose tolerance and type 2 diabetes mellitus. | Delorme, S. and Chiasson, JL. 2005. Curr Opin Pharmacol. 5: 184-9. PMID: 15780829
- Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial. | Chiasson, JL. 2006. Endocr Pract. 12 Suppl 1: 25-30. PMID: 16627376
- Acarbose: oral anti-diabetes drug with additional cardiovascular benefits. | Hanefeld, M. and Schaper, F. 2008. Expert Rev Cardiovasc Ther. 6: 153-63. PMID: 18248270
- The glucoamylase inhibitor acarbose is a direct activator of phosphorylase kinase. | Nadeau, OW., et al. 2010. Biochemistry. 49: 6505-7. PMID: 20604537
- Acarbose Monotherapy and Type 2 Diabetes Prevention in Eastern and Western Prediabetes: An Ethnicity-specific Meta-analysis. | Hu, R., et al. 2015. Clin Ther. 37: 1798-812. PMID: 26118669
- Important Aspects of Post-Prandial Antidiabetic Drug, Acarbose. | Singla, RK., et al. 2016. Curr Top Med Chem. 16: 2625-33. PMID: 27086787
- Acarbose improved survival for Apc+/Min mice. | Dodds, SG., et al. 2020. Aging Cell. 19: e13088. PMID: 31903726
- The human microbiome encodes resistance to the antidiabetic drug acarbose. | Balaich, J., et al. 2021. Nature. 600: 110-115. PMID: 34819672
- High-Fiber Diet or Combined With Acarbose Alleviates Heterogeneous Phenotypes of Polycystic Ovary Syndrome by Regulating Gut Microbiota. | Wang, X., et al. 2021. Front Endocrinol (Lausanne). 12: 806331. PMID: 35185786
- [Biosynthesis and regulatory mechanism of acarbose and its structural analogs: a review]. | Wang, Y., et al. 2022. Sheng Wu Gong Cheng Xue Bao. 38: 605-619. PMID: 35234385
- Combination therapy of bioactive compounds with acarbose: A proposal to control hyperglycemia in type 2 diabetes. | Uuh Narvaez, JJ. and Segura Campos, MR. 2022. J Food Biochem. 46: e14268. PMID: 35662051
- Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor acarbose (BAY g 5421). | Krause, HP., et al. 1982. Digestion. 23: 232-8. PMID: 6754513
- Acarbose. An update of its pharmacology and therapeutic use in diabetes mellitus. | Balfour, JA. and McTavish, D. 1993. Drugs. 46: 1025-54. PMID: 7510610
Inhibitor of:
α-Amylase, from Bacillus amyloliquefaciens, α-Amylase, from pig pancreas, α-FR, α-Glucosidase, β-1,4-GalNAc-T, β-FR, Acid Ceramidase, AGL, AI464131, AL-1, Amylase 1, Amylase 1a, Amylase 1b, Amylase 1c, Amylase 2, Amylase 2-2, Amylase 2A, Amylase 2a2, Amylase 2a3, Amylase 2a4, Amylase 2B, Amyloglucosidase, apoA-V, beta-glucosidase, CDKAL1, CRS4C-4, ENGase, EXD, FSBA, FUCA1, galectin-12, GalNAc-TL2, GalNAc-TL4, GANC, Gastric Lipase, GBE1, GIP, GLB1L3, GlcAT-I, Glucose Oxidase, Glucosidase, Glucosidase I, Glycogenin (GYG), HKDC1, hnRNP E3, Insulin, LCT, liver FBPase, LYAG, MagT1, Maltase-glucoamylase, MAN1C1, MANEA, MANEAL, Mpi, ND1, Olr14, Olr1591, Pancreatic Icosapeptide, PGM 2L1, PMM1, Reg IIIδ, SASPase, SCOT-t, Spint3, Sucrase-Isomaltase, TAG, Trehalase, and ZADH2.Activator of:
α-Amylase, from Bacillus amyloliquefaciens, α-Amylase, from pig pancreas, α-Glucosidase, ALDH9A1, ALG11, ALG1L, ALG1L2, Amylase 2a3, Amyloglucosidase, CARKD, CNDP2, G6PT, INS-IGF2, Insulinm Solution, Ketohexokinase, SDR16C6, SUR-1, and ZG16.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acarbose, 1 g | sc-203492 | 1 g | $226.00 | |||
Acarbose, 5 g | sc-203492A | 5 g | $605.00 |