Harpagoside (CAS 19210-12-9)
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Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil's Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.
Harpagoside (CAS 19210-12-9) References
- Efficacy and tolerance of Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. | Chantre, P., et al. 2000. Phytomedicine. 7: 177-83. PMID: 11185727
- Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. | Kaszkin, M., et al. 2004. Phytomedicine. 11: 585-95. PMID: 15636171
- Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. | Huang, TH., et al. 2006. J Ethnopharmacol. 104: 149-55. PMID: 16203115
- High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens. | Günther, M., et al. 2006. Phytochem Anal. 17: 1-7. PMID: 16454469
- Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. | Abdelouahab, N. and Heard, C. 2008. J Nat Prod. 71: 746-9. PMID: 18412394
- Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw). | Ouitas, NA. and Heard, C. 2010. Phytother Res. 24: 333-8. PMID: 19610038
- Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes. | Haseeb, A., et al. 2017. J Orthop Res. 35: 311-320. PMID: 27082319
- Harpagoside Rescues the Memory Impairments in Chronic Cerebral Hypoperfusion Rats by Inhibiting PTEN Activity. | Chen, C., et al. 2018. J Alzheimers Dis. 63: 445-455. PMID: 29614669
- Harpagoside attenuates local bone Erosion and systemic osteoporosis in collagen-induced arthritis in mice. | Kim, JY., et al. 2022. BMC Complement Med Ther. 22: 214. PMID: 35948905
- Antiinflammatory effects of different extracts and harpagoside isolated from Scrophularia frutescens L. | García, D., et al. 1996. Farmaco. 51: 443-6. PMID: 8766229
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Harpagoside, 5 mg | sc-203073 | 5 mg | $111.00 | |||
Harpagoside, 25 mg | sc-203073A | 25 mg | $428.00 |