Daphnetin (CAS 486-35-1)
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Daphnetin is widely used in biological research due to its properties as a coumarin derivative with multiple biochemical activities, including kinase inhibition. It is particularly valuable for studies aimed at understanding the modulation of cellular signaling pathways, such as those involving protein kinases like CK2 and PKA. Research involving Daphnetin focuses on its role in influencing these pathways, which are for cell cycle regulation, apoptosis, and differentiation. Additionally, Daphnetin is utilized in the study of its antioxidative properties, providing insights into how it interacts with reactive oxygen species and potentially protects cellular components from oxidative stress. Furthermore, due to its effects on various signaling molecules, Daphnetin is used in research exploring mechanisms of anti-inflammatory actions, which helps to understand its influence on cellular and physiological responses to inflammation.
Daphnetin (CAS 486-35-1) References
- Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. | Yang, EB., et al. 1999. Biochem Biophys Res Commun. 260: 682-5. PMID: 10403826
- Daphnetin: a novel antimalarial agent with in vitro and in vivo activity. | Yang, YZ., et al. 1992. Am J Trop Med Hyg. 46: 15-20. PMID: 1311154
- Activated oxygen generation by a primaquine metabolite: inhibition by antioxidants derived from Chinese herbal remedies. | Hong, YL., et al. 1992. Free Radic Biol Med. 12: 213-8. PMID: 1563647
- Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma. | Zhang, Y., et al. 2022. Food Funct. 13: 12383-12399. PMID: 36373505
- Antiplatelet Effect of Daphnetin Is Regulated by cPLA2-Mediated Thromboxane A2 Generation in Mice. | Chaudhary, PK., et al. 2023. Int J Mol Sci. 24: PMID: 36982853
- Effects of daphnetin on the mechanism of epithelial-mesenchymal transition induced by HMGB1 in human lung adenocarcinoma cells (A549 cell line). | Gong, SQ., et al. 2023. Biotechnol Genet Eng Rev. 1-22. PMID: 36994673
- Natural Coumarin Derivatives Activating Nrf2 Signaling Pathway as Lead Compounds for the Design and Synthesis of Intestinal Anti-Inflammatory Drugs. | Di Stasi, LC. 2023. Pharmaceuticals (Basel). 16: PMID: 37111267
- Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway. | Zhang, T., et al. 2023. Pharm Biol. 61: 746-754. PMID: 37177984
- Daphnetin attenuates intestinal inflammation, oxidative stress, and apoptosis in ulcerative colitis via inhibiting REG3A-dependent JAK2/STAT3 signaling pathway. | He, Z., et al. 2023. Environ Toxicol.. PMID: 37209277
- Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization. | Zhang, T., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37259390
- Daphnetin, a Coumarin with Anticancer Potential against Human Melanoma: In Vitro Study of Its Effective Combination with Selected Cytostatic Drugs. | Wróblewska-Łuczka, P., et al. 2023. Cells. 12: PMID: 37371063
- Daphnetin ameliorates PM2.5-induced airway inflammation by inhibiting NLRP3 inflammasome-mediated pyroptosis in CS-exposed mice. | Fan, X., et al. 2023. Biomed Pharmacother. 165: 115047. PMID: 37390709
- Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins. | Kimura, Y., et al. 1985. Biochim Biophys Acta. 834: 224-9. PMID: 3922420
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daphnetin, 10 mg | sc-203022 | 10 mg | $84.00 |