Date published: 2025-10-16

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Aniline (CAS 62-53-3)

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Alternate Names:
Phenylamine; Aminobenzene
Application:
Aniline is an oxidative stress, NF-κB and AP-1 inducer that has toxic effects on the spleen
CAS Number:
62-53-3
Purity:
≥99%
Molecular Weight:
93.13
Molecular Formula:
C6H7N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Aniline, a simple aromatic amine with the formula C6H5NH2, is a clear to slightly yellow liquid that is integral in the chemical industry for the synthesis of dyes, plastics, and various industrial chemicals. Originating from benzene, aniline features a highly reactive amino group attached to a phenyl ring, which is key to its use in electrophilic substitution reactions including acylation and halogenation, allowing for the creation of a wide range of derivative compounds. In materials science research, aniline is particularly valued for its capability to polymerize into polyaniline, a conductive polymer whose electrical properties can be finely adjusted through chemical doping processes. These properties make it suitable for applications in anti-static coatings, rechargeable battery components, and electronic sensors. Furthermore, aniline′s utility extends to the production of methylene diphenyl diisocyanate (MDI), a critical precursor in manufacturing polyurethanes used in everything from foams to adhesives. Its versatility is further demonstrated in its role in creating rubber processing chemicals and antioxidants, highlighting aniline′s broad applicability across multiple domains of industrial chemistry and materials science.


Aniline (CAS 62-53-3) References

  1. Mechanistic study on aniline-induced erythrocyte toxicity.  |  Singh, H., et al. 2007. Arh Hig Rada Toksikol. 58: 275-85. PMID: 17913681
  2. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline.  |  Wang, J., et al. 2008. Toxicol Appl Pharmacol. 230: 227-34. PMID: 18420242
  3. Up-regulation of heme oxygenase-1 in rat spleen after aniline exposure.  |  Wang, J., et al. 2010. Free Radic Biol Med. 48: 513-8. PMID: 19969074
  4. Decomposition of aniline in aqueous solution by UV/TiO2 process with applying bias potential.  |  Ku, Y., et al. 2010. J Hazard Mater. 183: 16-21. PMID: 20691533
  5. Efficient bio-deodorization of aniline vapor in a biotrickling filter: metabolic mineralization and bacterial community analysis.  |  Li, G., et al. 2012. Chemosphere. 87: 253-8. PMID: 22236589
  6. Rapid removal of aniline from contaminated water by a novel polymeric adsorbent.  |  Huang, Y., et al. 2014. Water Environ Res. 86: 20-7. PMID: 24617106
  7. Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion.  |  Leiva, R., et al. 2018. J Med Chem. 61: 98-118. PMID: 29220568
  8. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds.  |  Bus, JS. and Popp, JA. 1987. Food Chem Toxicol. 25: 619-26. PMID: 3305247
  9. Differences in Pharmacokinetics and Haematotoxicities of Aniline and Its Dimethyl Derivatives Orally Administered in Rats.  |  Miura, T., et al. 2021. Biol Pharm Bull. 44: 1775-1780. PMID: 34433705
  10. Chemical characterization of anemia-inducing aniline-related substances and their application to the construction of a decision tree-based anemia prediction model.  |  Asai, T., et al. 2021. Food Chem Toxicol. 157: 112548. PMID: 34509582
  11. Stimulation of 3,4-dichloroaniline mineralization by aniline.  |  You, IS. and Bartha, R. 1982. Appl Environ Microbiol. 44: 678-81. PMID: 7138005

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Aniline, 5 g

sc-202952
5 g
$26.00

Aniline, 100 g

sc-202952A
100 g
$32.00

Aniline, 500 g

sc-202952B
500 g
$72.00