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Acetylcholine chloride (CAS 60-31-1)

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Alternate Names:
2-(Acetyloxy)-N,N,N-trimethylethanaminium chloride; 2-Acetoxyethyltrimethylammonium chloride
Application:
Acetylcholine chloride is a cholinergic neurotransmitter that binds to nicotinic and muscarinic acetylcholine receptors and can induce the opening of calcium channels.
CAS Number:
60-31-1
Purity:
≥99%
Molecular Weight:
181.66
Molecular Formula:
C7H16NO2•Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Acetylcholine chloride is a compound utilized in various research applications, particularly within the fields of neuroscience and physiology. It is an ester of acetic acid and choline, and due to its role as a neurotransmitter, it is of interest in the study of cholinergic systems in both the central and peripheral nervous systems. Research involving acetylcholine chloride focuses on its involvement in synaptic transmission, where it binds to and activates acetylcholine receptors, leading to a range of physiological responses. The compound is also used in studies of muscle contraction, as it is the primary neurotransmitter at neuromuscular junctions, and is essential for the activation of muscle fibers. In addition, acetylcholine chloride is a tool in electrophysiological experiments, where it is applied to study the responses of neurons and muscle cells to cholinergic stimulation. This research contributes to understanding the complex processes underlying neurotransmission and the function of acetylcholine in various biological systems.


Acetylcholine chloride (CAS 60-31-1) References

  1. The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans.  |  Wessler, I., et al. 1999. Clin Exp Pharmacol Physiol. 26: 198-205. PMID: 10081614
  2. Acetylcholine in mind: a neurotransmitter correlate of consciousness?  |  Perry, E., et al. 1999. Trends Neurosci. 22: 273-80. PMID: 10354606
  3. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells.  |  Lei, X., et al. 2008. Arch Dermatol Res. 300: 335-41. PMID: 18386025
  4. Biomimetically synthesized silica-carbon nanofiber architectures for the development of highly stable electrochemical biosensor systems.  |  Vamvakaki, V., et al. 2008. Anal Chem. 80: 5970-5. PMID: 18593196
  5. Perception of dyspnea during acetylcholine-induced bronchoconstriction in asthmatic children.  |  Motomura, C., et al. 2009. Ann Allergy Asthma Immunol. 102: 121-4. PMID: 19230462
  6. A novel method developed for acetylcholine detection in royal jelly by using capillary electrophoresis coupled with electrogenerated chemiluminescence based on a simple reaction.  |  Wei, W., et al. 2009. Electrophoresis. 30: 1949-52. PMID: 19517434
  7. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production.  |  Zabrodskii, PF. 2011. Bull Exp Biol Med. 150: 340-2. PMID: 21240349
  8. [Role of acetylcholine in gelsenicine-induced death in mice].  |  Lai, ZY., et al. 2016. Sheng Li Xue Bao. 68: 249-54. PMID: 27350197
  9. Specific Encapsulation of Acetylcholine Chloride by a Self-Assembled Molecular Capsule with Sulfonamido Moiety.  |  Park, YS., et al. 2019. Org Lett. 21: 8300-8303. PMID: 31560557
  10. Herbicidal Ionic Liquids Containing the Acetylcholine Cation.  |  Czuryszkiewicz, D., et al. 2019. Chempluschem. 84: 268-276. PMID: 31950757
  11. Hydration and counterion binding of aqueous acetylcholine chloride and carbamoylcholine chloride.  |  Friesen, S., et al. 2021. Phys Chem Chem Phys. 23: 25086-25096. PMID: 34747952
  12. Dequalinium chloride is an antagonists of α7 nicotinic acetylcholine receptors.  |  Belanger-Coast, MG., et al. 2022. Eur J Pharmacol. 925: 175000. PMID: 35525312
  13. Sensitive and specific electrochemical sensors for charge-diffuse cations: use of lipophilic cyclodextrins and an enzyme relay for the determination of acetylcholine.  |  Kataky, R. and Parker, D. 1996. Analyst. 121: 1829-34. PMID: 9008405
  14. Acetylcholine release and the cholinergic genomic locus.  |  Israël, M. and Dunant, Y. 1998. Mol Neurobiol. 16: 1-20. PMID: 9554699
  15. The acetylcholine, GABA, glutamate triangle in the rat forebrain.  |  Pepeu, G. and Blandina, P. 1998. J Physiol Paris. 92: 351-5. PMID: 9789836

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Acetylcholine chloride, 5 g

sc-202904
5 g
$42.00

Acetylcholine chloride, 25 g

sc-202904A
25 g
$62.00

Acetylcholine chloride, 100 g

sc-202904B
100 g
$185.00

Acetylcholine chloride, 250 g

sc-202904C
250 g
$398.00

Acetylcholine chloride, 1 kg

sc-202904D
1 kg
$1438.00

Dose Ach contains fish?

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Date published: 2021-07-22
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Rated 5 out of 5 by from LeiLei, X. et al. (PubMed 18386025) investigated the effects of Acetylcholine chloride (ACh) on intracellular calcium concentration of cultured sweat gland epithelial cells. After the ACh was added, when the medium with high calcium (2 mmol/L) was applied, the calcium channel of both primary and first passage cells opened and significant [Ca(2+)](I )increase was observed; when the medium with no calcium was applied, no significant [Ca(2+)](i )increase was observed. -SCBT Publication Review
Date published: 2015-01-02
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Acetylcholine chloride is rated 5.0 out of 5 by 1.
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