Sanguinarine chloride (CAS 5578-73-4)
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Sanguinarium Chloride, also known as Sanguinarine, is a natural alkaloid compound derived from various plant species within the Sanguinaria genus. It may act to impede the activity of enzymes responsible for DNA, RNA, and protein biosynthesis. Additionally, it disrupts the production of proinflammatory cytokines, thereby modulating the inflammatory response. Furthermore, it suppresses the production of T-cells and B-cells. Although the precise mechanism of action of sanguinarium chloride is not entirely elucidated, it is believed to interact with and inhibit the activity of enzymes involved in DNA, RNA, and protein biosynthesis. Furthermore, sanguinarium chloride has demonstrated the ability to disrupt the production of proinflammatory cytokines, essential molecules involved in inflammatory responses.
Sanguinarine chloride (CAS 5578-73-4) References
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- Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt. | Han, MH., et al. 2007. Anticancer Drugs. 18: 913-21. PMID: 17667597
- Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. | Aburai, N., et al. 2010. Biosci Biotechnol Biochem. 74: 548-52. PMID: 20208361
- Characterization and assessment of nanoencapsulated sanguinarine chloride as a potential treatment for melanoma. | Rosen, J., et al. 2015. J Drugs Dermatol. 14: 453-8. PMID: 25942662
- Natural compound sanguinarine chloride targets the type III secretion system of Salmonella enterica Serovar Typhimurium. | Zhang, Y., et al. 2018. Biochem Biophys Rep. 14: 149-154. PMID: 29761161
- Effect of Sanguinarine chloride on proliferation and apoptosis of human tongue cancer cells and its mechanism. | Du, Y., et al. 2023. Panminerva Med. 65: 104-106. PMID: 32759910
- The Antiangiogenic Effect of Sanguinarine Chloride on Experimental Choroidal Neovacularization in Mice via Inhibiting Vascular Endothelial Growth Factor. | Zhang, J., et al. 2021. Front Pharmacol. 12: 638215. PMID: 33790794
- Epidemic dropsy toxin, sanguinarine chloride, stimulates sucrose-sensitive hemolysis and breakdown of membrane phospholipid asymmetry in human erythrocytes. | Alfhili, MA., et al. 2021. Toxicon. 199: 41-48. PMID: 34081931
- Natural compound library screening identifies Sanguinarine chloride for the treatment of SCLC by upregulating CDKN1A. | Zhong, M., et al. 2022. Transl Oncol. 17: 101345. PMID: 35066462
- Natural Product Library Screens Identify Sanguinarine Chloride as a Potent Inhibitor of Telomerase Expression and Activity. | Yan, S., et al. 2022. Cells. 11: PMID: 35563795
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sanguinarine chloride, 5 mg | sc-202800 | 5 mg | $184.00 |